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Journal article
Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children
The journal of allergy and clinical immunology. Global, v 3(3), 100248
01 Aug 2024
PMID: 38645670
Abstract
Outdoor aeroallergens, such as pollens and molds, are known triggers of asthma exacerbation; however, few studies have examined children’s aeroallergen response based on sensitization.
Our aim was to compare the relative impact of aeroallergen levels on asthma exacerbation between pediatric patients with asthma who tested positive or negative for sensitization to particular allergens.
A case-crossover design study was conducted to examine associations between outdoor aeroallergen levels and asthma exacerbation events among children living in Philadelphia, Pennsylvania, who were treated within a large pediatric care network. Sensitization to common allergens was characterized in a subset of patients with asthma exacerbation who had undergone skin prick testing (5.5%). Odds ratios (ORs) and 95% CIs were estimated in all patients with asthma exacerbation and in those sensitized or not sensitized to aeroallergens.
Children who were sensitized to a particular allergen had higher odds of asthma exacerbation with exposure to the allergen (ie, early-season tree pollen, oak tree pollen, early-season weed pollen, and late-season molds) than did all patients with asthma or nonsensitized patients. For example, the association between early-season tree pollen and asthma exacerbation among sensitized children (>90th percentile vs ≤25th, OR = 2.28 [95% CI = 1.23-4.22]) was considerably stronger than that estimated among all patients (OR = 1.34 [95% CI = 1.19-1.50]), and it was also substantially different from the lack of association seen among nonsensitized children (OR = 0.89 [95% CI = 0.51-1.55] [P value for heterogeneity = .03]).
More prevalent allergy testing may be useful for prevention of asthma exacerbation by informing interventions targeted to sensitized children and tailored for particular aeroallergens.
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Details
- Title
- Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children
- Creators
- Anneclaire J. De Roos - Drexel University, Urban Health CollaborativeJames P. Senter - Children's Hospital of PhiladelphiaLeah H. Schinasi - Drexel University, Urban Health CollaborativeWanyu Huang - Drexel University, Epidemiology and BiostatisticsKari Moore - Drexel University, Urban Health CollaborativeMitchell Maltenfort - Rothman InstituteChristopher Forrest - Children's Hospital of PhiladelphiaSarah E. Henrickson - Children's Hospital of PhiladelphiaChén C. Kenyon - Children's Hospital of Philadelphia
- Publication Details
- The journal of allergy and clinical immunology. Global, v 3(3), 100248
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Environmental and Occupational Health
- Scopus ID
- 2-s2.0-85191171185
- Other Identifier
- 991022019814404721