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Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children
Journal article   Open access   Peer reviewed

Outdoor aeroallergen impacts on asthma exacerbation among sensitized and nonsensitized Philadelphia children

Anneclaire J. De Roos, James P. Senter, Leah H. Schinasi, Wanyu Huang, Kari Moore, Mitchell Maltenfort, Christopher Forrest, Sarah E. Henrickson and Chén C. Kenyon
The journal of allergy and clinical immunology. Global, v 3(3), 100248
01 Aug 2024
DOI: https://doi.org/10.1016/j.jacig.2024.100248
PMID: 38645670
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11024998View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open
url
https://doi.org/10.1016/j.jacig.2024.100248View
Published, Version of Record (VoR) Open

Abstract

aeroallergen allergy mold Pediatric asthma pollen seasonal
Outdoor aeroallergens, such as pollens and molds, are known triggers of asthma exacerbation; however, few studies have examined children’s aeroallergen response based on sensitization. Our aim was to compare the relative impact of aeroallergen levels on asthma exacerbation between pediatric patients with asthma who tested positive or negative for sensitization to particular allergens. A case-crossover design study was conducted to examine associations between outdoor aeroallergen levels and asthma exacerbation events among children living in Philadelphia, Pennsylvania, who were treated within a large pediatric care network. Sensitization to common allergens was characterized in a subset of patients with asthma exacerbation who had undergone skin prick testing (5.5%). Odds ratios (ORs) and 95% CIs were estimated in all patients with asthma exacerbation and in those sensitized or not sensitized to aeroallergens. Children who were sensitized to a particular allergen had higher odds of asthma exacerbation with exposure to the allergen (ie, early-season tree pollen, oak tree pollen, early-season weed pollen, and late-season molds) than did all patients with asthma or nonsensitized patients. For example, the association between early-season tree pollen and asthma exacerbation among sensitized children (>90th percentile vs ≤25th, OR = 2.28 [95% CI = 1.23-4.22]) was considerably stronger than that estimated among all patients (OR = 1.34 [95% CI = 1.19-1.50]), and it was also substantially different from the lack of association seen among nonsensitized children (OR = 0.89 [95% CI = 0.51-1.55] [P value for heterogeneity = .03]). More prevalent allergy testing may be useful for prevention of asthma exacerbation by informing interventions targeted to sensitized children and tailored for particular aeroallergens.

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