Journal article
Overexpression of Bcl‐2 is neuroprotective after experimental brain injury in transgenic mice
Journal of comparative neurology (1911), v 412(4), pp 681-692
04 Oct 1999
PMID: 10464363
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Abstract
The cell death regulatory protein, Bcl‐2, has been suggested to participate in the pathophysiology of various neurological disorders, including traumatic brain injury (TBI). The cognitive function and histopathologic sequelae after controlled cortical impact brain injury were evaluated in transgenic (TG) mice that overexpress human Bcl‐2 protein (n = 13) and their wild type (WT) controls (n = 9). Although brain‐injured Bcl‐2 TG mice exhibited similar posttraumatic deficits in a Morris water maze (MWM) test of spatial memory as their WT counterparts at 1 week postinjury, the preinjury learning ability of Bcl‐2 TG mice was impaired significantly compared with their WT littermates (P < 0.05). In contrast, histopathologic analysis revealed significantly attenuated tissue loss in the ipsilateral hemisphere (p < 0.01) and decreased tissue loss in ipsilateral hippocampal area CA3 (P < 0.001) and the dentate gyrus (P < 0.01) in brain‐injured Bcl‐2 TG mice compared with brain‐injured WT mice. Immunohistochemical evaluation of glial fibrillary acidic protein also revealed a significant decrease in reactive astrocytosis in the ipsilateral dorsal thalamus (P < 0.05) and the ventral thalamus (P < 0.01) in brain‐injured Bcl‐2 TG mice. These results suggest that overexpression of Bcl‐2 protein may play a protective role in neuropathologic sequelae after TBI. J. Comp. Neurol. 412:681–692, 1999. © 1999 Wiley‐Liss, Inc.
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Details
- Title
- Overexpression of Bcl‐2 is neuroprotective after experimental brain injury in transgenic mice
- Creators
- Michio Nakamura - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaRamesh Raghupathi - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaDiane E Merry - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaUwe Scherbel - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaKathryn E Saatman - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaTracy K Mcintosh - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
- Publication Details
- Journal of comparative neurology (1911), v 412(4), pp 681-692
- Publisher
- John Wiley & Sons, Inc; New York
- Number of pages
- 12
- Grant note
- Muscular Dystrophy Association Veterans Administration National Institute for General Medical Science (RO1‐GM34690) Brain Injury Association National Institute of Neurological Disorders and Stroke (P50‐NS08803; RO1‐NS26818) National Institutes of Health (R29 NS36248; RO1 NS32214)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000082241100009
- Scopus ID
- 2-s2.0-0033523589
- Other Identifier
- 991014878316404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Zoology