Journal article
Oxidative Stress in Chagas Disease
Interdisciplinary perspectives on infectious diseases, v 2009
2009
PMID: 19547716
Abstract
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression. Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) during acute infection. Mitochondria are proposed to be the major source of ROS in chronic chagasic hearts. However, it has not been established yet, whether mitochondrial dysfunction is a causative factor in chagasic cardiomyopathy or a consequence of other pathological events. A better understanding of oxidative stress in relation to cardiac tissue damage would be useful in the evaluation of its true role in the pathogenesis of Chagas disease and other heart diseases. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, and its role in sustaining oxidative stress in myocardium.
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Details
- Title
- Oxidative Stress in Chagas Disease
- Creators
- Shivali Gupta - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAJian-Jun Wen - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USANisha Jain Garg - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
- Publication Details
- Interdisciplinary perspectives on infectious diseases, v 2009
- Publisher
- Hindawi Publishing Corporation
- Resource Type
- Journal article
- Language
- English
- Other Identifier
- 991014878464004721