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Journal article
P11 expression and PET in bipolar disorders
Journal of psychiatric research, v 45(11), pp 1426-1431
2011
PMID: 21722919
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Abstract
Bipolar disorder (BD) is a common mental disorder, subdivided into BD-I and BD-II. Currently, few biomarkers differentiate BD-I from BD-II. However, it is suggested that peripheral blood mononuclear cell (PBMC) mRNA levels of p11 and positron emission tomography (PET) might be potential biomarkers for BD.
Healthy controls (HCs), BD-I, and BD-II patients in remission (
n = 20 in each group) underwent a resting PET study with the radiotracer [
18F]-2-deoxy-2-fluoro-
d-glucose (
18F-FDG). PBMC p11 mRNA levels were determined by quantitative real-time PCR.
Comparing BD patients to HCs, normalized glucose metabolism (NGM) was higher in the hippocampus, parahippocampus, and amygdala, but lower in the anterior cingulate cortex (aCC), medial prefrontal cortex (mPFC), dorsolateral prefrontal cortex (dlPFC), insula and thalamus. Compared to BD-II, BD-I had hypometabolism of glucose in the aCC, bilateral middle and inferior gyrus, insula and striatum, and hypermetabolism of glucose in the left parahippocampus. PBMC p11 mRNA was over-expressed in both BD-I and BD-II, although there was no significant difference in its expression levels between BD-I and B-II patients. Further, there were significant positive correlations between PBMC p11 mRNA and NGM in the mPFC, aCC, left insula, bilateral orbitofrontal cortex (OFC), and left middle, inferior and superior temporal gyri. Also, PBMC p11 mRNA was positively correlated to the number of depressive episodes in BD patients, especially in BD-I patients.
This study demonstrates that PBMC p11 mRNA expression is associated with neural activation in the brain of BD patients and warrants a larger translational study to determine its clinical utility.
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Details
- Title
- P11 expression and PET in bipolar disorders
- Creators
- Lei Zhang - Uniformed Services University of the Health SciencesCheng-Ta Li - Taipei Veterans General HospitalTung-Ping Su - Taipei Veterans General HospitalXian-Zhang Hu - Uniformed Services University of the Health SciencesRuth A. Lanius - London Health Sciences CentreMaree J. Webster - Stanley Medical Research InstituteMing-Yi Chung - National Yang-Ming UniversityYing-Sheue Chen - National Yang-Ming UniversityYa-Mei Bai - National Yang-Ming UniversityJeffery L. Barker - National Institute of Neurological Disorders and StrokeJames E. Barrett - Drexel UniversityXiao-Xia Li - Uniformed Services University of the Health SciencesHe Li - Uniformed Services University of the Health SciencesDavid M. Benedek - Uniformed Services University of the Health SciencesRobert Ursano - Uniformed Services University of the Health Sciences
- Publication Details
- Journal of psychiatric research, v 45(11), pp 1426-1431
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000296688100003
- Scopus ID
- 2-s2.0-80053948906
- Other Identifier
- 991019168211804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry