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PATTERN GENERATING NETWORKS IN THE HUMAN LUMBAR SPINAL CORD: ELECTROPHYSIOLOGY AND COMPUTER MODELING
Journal article   Open access   Peer reviewed

PATTERN GENERATING NETWORKS IN THE HUMAN LUMBAR SPINAL CORD: ELECTROPHYSIOLOGY AND COMPUTER MODELING

S. M. Danner, F. Rattay, U. S. Hofstoetter, M. R. Dimitrijevic and K. Minassian
Biomedizinische Technik, v 58
01 Aug 2013
DOI: https://doi.org/10.1515/bmt-2013-4012
PMID: 24042600
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.degruyter.com/document/doi/10.1515/bmt-2013-4012/pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1515/bmt-2013-4012View
Published, Version of Record (VoR) Open

Abstract

Engineering Engineering, Biomedical Life Sciences & Biomedicine Medical Informatics Science & Technology Technology
Epidural spinal cord stimulation can produce rhythmic motor output to the lower limbs of motor complete spinal cord injury people. The electromyographically recorded activity consists of a series of modulated stimulus time-related compound muscle action potentials (CMAPs). Here, we investigate phase dependent modification of the CMAP latencies and present a computer model that mechanistically describes putative locomotor pattern generating circuitries of the human lumbar spinal cord. Thereby we gained insight into the organization of the human spinal pattern generating networks, revealed common control characteristics with the central pattern generators for locomotion described in animal experimental work and highlighted specifities of the studied model.

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Engineering, Biomedical
Medical Informatics
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