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Journal article
PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy
Advanced materials (Weinheim), v 30(22), pp e1707112-n/a
29 May 2018
PMID: 29656492
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cancer cells resist to the host immune antitumor response via multiple suppressive mechanisms, including the overexpression of PD-L1 that exhausts antigen-specific CD8(+) T cells through PD-1 receptors. Checkpoint blockade antibodies against PD-1 or PD-L1 have shown unprecedented clinical responses. However, limited host response rate underlines the need to develop alternative engineering approaches. Here, engineered cellular nanovesicles (NVs) presenting PD-1 receptors on their membranes, which enhance antitumor responses by disrupting the PD-1/PD-L1 immune inhibitory axis, are reported. PD-1 NVs exhibit a long circulation and can bind to the PD-L1 on melanoma cancer cells. Furthermore, 1-methyl-tryptophan, an inhibitor of indoleamine 2,3-dioxygenase can be loaded into the PD-1 NVs to synergistically disrupt another immune tolerance pathway in the tumor microenvironment. Additionally, PD-1 NVs remarkably increase the density of CD8(+) tumor infiltrating lymphocytes in the tumor margin, which directly drive tumor regression.
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Details
- Title
- PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy
- Creators
- Xudong Zhang - Shenzhen University Health Science CenterChao Wang - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USAJinqiang Wang - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USAQuanyin Hu - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USABenjamin Langworthy - University of North Carolina at Chapel HillYanqi Ye - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USAWujin Sun - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USAJing Lin - Shenzhen University Health Science CenterTianfu Wang - Shenzhen University Health Science CenterJason Fine - University of North Carolina at Chapel HillHao Cheng - Drexel UniversityGianpietro Dotti - University of North Carolina at Chapel HillPeng Huang - Shenzhen University Health Science CenterZhen Gu - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
- Publication Details
- Advanced materials (Weinheim), v 30(22), pp e1707112-n/a
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- 2017M612742 / China Postdoctoral Science Foundation JCYJ20170412111100742; JCYJ20160422091238319 / Basic Research Program of Shenzhen 31771036; 51703132; 51573096; 81401465 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) University of North Carolina (UNC) Cancer Center Alfred P. Sloan Foundation 1L1TR001111 / NC TraCS, the National Institutes of Health (Clinical and Translational Science Award (CTSA, NIH)); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 161032 / Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China; Fok Ying Tung Education Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000434034100014
- Scopus ID
- 2-s2.0-85045477819
- Other Identifier
- 991019168980904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter