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Journal article
PET-Based Imaging with F-18-FDG and F-18-NaF to Assess Inflammation and Microcalcification in Atherosclerosis and Other Vascular and Thrombotic Disorders
Diagnostics (Basel), v 11(12)
01 Dec 2021
PMID: 34943473
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Positron emission tomography (PET) imaging with F-18-fluorodeoxyglucose (FDG) represents a method of detecting and characterizing arterial wall inflammation, with potential applications in the early assessment of vascular disorders such as atherosclerosis. By portraying early-stage molecular changes, FDG-PET findings have previously been shown to correlate with atherosclerosis progression. In addition, recent studies have suggested that microcalcification revealed by F-18-sodium fluoride (NaF) may be more sensitive at detecting atherogenic changes compared to FDG-PET. In this review, we summarize the roles of FDG and NaF in the assessment of atherosclerosis and discuss the role of global assessment in quantification of the vascular disease burden. Furthermore, we will review the emerging applications of FDG-PET in various vascular disorders, including pulmonary embolism, as well as inflammatory and infectious vascular diseases.
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Details
- Title
- PET-Based Imaging with F-18-FDG and F-18-NaF to Assess Inflammation and Microcalcification in Atherosclerosis and Other Vascular and Thrombotic Disorders
- Creators
- William Y. Raynor - Drexel University, Radiology (Radiologic Sciences)Peter Sang Uk Park - Hospital of the University of PennsylvaniaAustin J. Borja - Hospital of the University of PennsylvaniaYusha Sun - College Station Medical CenterThomas J. Werner - Hospital of the University of PennsylvaniaSze Jia Ng - College Station Medical CenterHui Chong Lau - College Station Medical CenterPoul Flemming Hoilund-Carlsen - College Station Medical CenterAbass Alavi - Hospital of the University of PennsylvaniaMona-Elisabeth Revheim - Hospital of the University of Pennsylvania
- Publication Details
- Diagnostics (Basel), v 11(12)
- Publisher
- Mdpi
- Number of pages
- 30
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000736665700001
- Scopus ID
- 2-s2.0-85121556109
- Other Identifier
- 991019350573304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging