Journal article
PIGMENTED VILLONODULAR SYNOVITIS A Comprehensive Review and Proposed Treatment Algorithm
JBJS reviews, v 4(7)
05 Jul 2016
PMID: 27509331
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved.
Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules.
The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method.
Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition.
Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.
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Details
- Title
- PIGMENTED VILLONODULAR SYNOVITIS A Comprehensive Review and Proposed Treatment Algorithm
- Creators
- Stephen R. Stephan - Drexel UniversityBrandon Shallop - Drexel UniversityRichard Lackman - Cooper University HospitalTae Won B. Kim - Cooper University HospitalMary K. Mulcahey - Drexel University
- Publication Details
- JBJS reviews, v 4(7)
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Orthopedic/Orthopaedic Surgery
- Web of Science ID
- WOS:000382451900003
- Scopus ID
- 2-s2.0-85028790671
- Other Identifier
- 991019169676604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery