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Journal article
PRIGo: a new multi-axis goniometer for macromolecular crystallography
Journal of synchrotron radiation, v 22(4), pp 895-900
01 Jul 2015
PMID: 26134792
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Parallel Robotics Inspired Goniometer (PRIGo) is a novel compact and high-precision goniometer providing an alternative to (mini-)kappa, traditional three-circle goniometers and Eulerian cradles used for sample reorientation in macromolecular crystallography. Based on a combination of serial and parallel kinematics, PRIGo emulates an arc. It is mounted on an air-bearing stage for rotation around omega and consists of four linear positioners working synchronously to achieve x, y, z translations and chi rotation (0-90 degrees), followed by a phi stage (0-360 degrees) for rotation around the sample holder axis. Owing to the use of piezo linear positioners and active correction, PRIGo features spheres of confusion of < 1 mu m, < 7 mu m and < 10 mu m for omega, chi and phi, respectively, and is therefore very well suited for micro-crystallography. PRIGo enables optimal strategies for both native and experimental phasing crystallographic data collection. Herein, PRIGo hardware and software, its calibration, as well as applications in macromolecular crystallography are described.
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Details
- Title
- PRIGo: a new multi-axis goniometer for macromolecular crystallography
- Creators
- Sandro Waltersperger - Paul Scherrer InstituteVincent Olieric - Paul Scherrer InstituteClaude Pradervand - Paul Scherrer InstituteWayne Glettig - Swiss Center for Electronics and MicrotechnologyMarco Salathe - Paul Scherrer InstituteMartin R. Fuchs - Paul Scherrer InstituteAdrian Curtin - Paul Scherrer InstituteXiaoqiang Wang - Paul Scherrer InstituteSimon Ebner - Paul Scherrer InstituteEzequiel Panepucci - Paul Scherrer InstituteTobias Weinert - Paul Scherrer InstituteClemens Schulze-Briese - Tris PharmaMeitian Wang - Paul Scherrer InstituteBrookhaven National Laboratory (BNL), Upton, NY (United States)
- Publication Details
- Journal of synchrotron radiation, v 22(4), pp 895-900
- Publisher
- Int Union Crystallography
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000357407900004
- Scopus ID
- 2-s2.0-84937390035
- Other Identifier
- 991019176798204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Instruments & Instrumentation
- Optics
- Physics, Applied