Journal article
PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium
Blood, v 120(23), pp 4645-4648
29 Nov 2012
PMID: 23047821
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic
BCL2L11
gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21,
P
random = 2.21 × 10
−11
), with similar risk estimates for common B-cell subtypes.
PRRC2A
rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68,
P
random = 1.07 × 10
−9
) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.
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Details
- Title
- PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium
- Creators
- Alexandra Nieters - University Medical Center FreiburgLucia Conde - University of California, BerkeleySusan L. Slager - Mayo Clinic College of Medicine Rochester, MNAngela Brooks-Wilson - Simon Fraser UniversityLindsay Morton - Department of Health and Human ServicesDanica R. Skibola - University of California, BerkeleyAnne J. Novak - Mayo Clinic College of Medicine Rochester, MNJacques Riby - University of California, BerkeleyStephen M. Ansell - Mayo Clinic College of Medicine Rochester, MNEran Halperin - Tel Aviv UniversityTait D. Shanafelt - Mayo Clinic College of Medicine Rochester, MNLuz Agana - University of California, BerkeleyAlice H. Wang - Mayo Clinic College of Medicine Rochester, MNAnneclaire J. De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaRichard K. Severson - The Barbara Ann Karmanos Cancer InstituteWendy Cozen - University of Southern CaliforniaJohn Spinelli - BC Cancer Research CentreKatja Butterbach - German Cancer Research CenterNikolaus Becker - German Cancer Research CenterSilvia de Sanjose - Institut Català d'OncologiaYolanda Benavente - Institut Català d'OncologiaPierluigi Cocco - University of CagliariAnthony Staines - Dublin City UniversityMarc Maynadié - Université de BourgogneLenka Foretova - Department of Cancer Epidemiology and Genetics, Brno, Czech Republic;Paolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - Centre international de recherche sur le cancerQing Lan - Yale UniversityYawei Zhang - Yale UniversityTongzhang Zheng - Yale UniversityMark Purdue - Department of Health and Human ServicesBruce Armstrong - The University of SydneyAnne Kricker - The University of SydneyClaire M. Vajdic - UNSW SydneyAndrew Grulich - UNSW SydneyMartyn T. Smith - University of California, BerkeleyPaige M. Bracci - University of California, San FranciscoStephen J. Chanock - Department of Health and Human ServicesPatricia Hartge - Department of Health and Human ServicesJames R. Cerhan - Mayo Clinic College of Medicine Rochester, MNSophia S. Wang - City of HopeNathaniel Rothman - Department of Health and Human ServicesChristine F. Skibola - University of California, Berkeley
- Publication Details
- Blood, v 120(23), pp 4645-4648
- Publisher
- American Society of Hematology
- Grant note
- CA122663; CA154643-01A1; CA104682; NO1-CO-12400; CA92153 / National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000313113300029
- Scopus ID
- 2-s2.0-84870541309
- Other Identifier
- 991020099057204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Hematology