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Pain and Sleep Biomarkers in Participants Undergoing Orthopedic Surgeries
Journal article   Open access   Peer reviewed

Pain and Sleep Biomarkers in Participants Undergoing Orthopedic Surgeries

Manish Bhomia, Nicholas A. Giordano, Krista B. Highland, Keren Lee, Matthew Van Shufflin, Yanru Feng, Alexandra Kane, Raymond B. Kroma and Barbara Knollmann-Ritschel
International journal of molecular sciences, v 26(13), 5959
01 Jul 2025
DOI: https://doi.org/10.3390/ijms26135959
PMID: 40649738
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3390/ijms26135959View
Published, Version of Record (VoR) Open

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Life Sciences & Biomedicine Science & Technology Physical Sciences
The bidirectional relationship between chronic pain and poor sleep are well reported. Disrupted sleep and chronic pain, either alone or in conjunction, are often associated with poor post-surgical outcomes. However, the relationship between peripheral blood biomarkers and chronic pain and sleep disturbances after orthopedic surgery has not been extensively studied. The goal of this observational prospective study was to conduct an analysis on the relationship of blood cytokines and chemokines with chronic pain and sleep outcomes among US service members undergoing orthopedic surgery. Active-duty service members (N = 114) who underwent orthopedic extremity or spinal surgery were recruited, of whom 69 completed pre-surgery and 64 completed 6-week post-surgery surveys and blood draws. Blood cytokine and chemokine analyses were performed using multiplex immunoassays. Non-parametric correlations with blood cytokine and chemokine showed significant associations with both pre- and post-surgical pain scores whereas no significant correlations were observed with sleep disturbance scores. Increased pain intensity 6 weeks after surgery was positively associated with increased hepatocyte growth factor (rho(s) = 0.11; p < 0.05) and negatively correlated with interleukin-2r (rho(s)= -0.42; p < 0.001). This study found that inflammatory biomarkers are associated with pre- and post-surgical pain but not sleep disturbances.

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: SDGs in the Output

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Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
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