Journal article
Painting blood vessels and atherosclerotic plaques with an adhesive drug depot
Proceedings of the National Academy of Sciences - PNAS, v 109(52), pp 21444-21449
26 Dec 2012
PMID: 23236189
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drug-eluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.
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Details
- Title
- Painting blood vessels and atherosclerotic plaques with an adhesive drug depot
- Creators
- Christian J. Kastrup - University of British ColumbiaMatthias Nahrendorf - Center for Systems BiologyJose Luiz Figueiredo - Center for Systems BiologyHaeshin Lee - Korea Advanced Institute of Science and TechnologySwetha Kambhampati - aDavid H. Koch Institute for Integrated Cancer Research andTimothy Lee - aDavid H. Koch Institute for Integrated Cancer Research andSeung-Woo Cho - Yonsei UniversityRostic Gorbatov - Center for Systems BiologyYoshiko Iwamoto - Center for Systems BiologyTram T. Dang - aDavid H. Koch Institute for Integrated Cancer Research andPartha Dutta - Center for Systems BiologyJu Hun Yeon - University of British ColumbiaHao Cheng - Drexel UniversityChristopher D. Pritchard - aDavid H. Koch Institute for Integrated Cancer Research andArturo J. Vegas - aDavid H. Koch Institute for Integrated Cancer Research andCory D. Siegel - Center for Systems BiologySamantha MacDougall - aDavid H. Koch Institute for Integrated Cancer Research andMichael Okonkwo - aDavid H. Koch Institute for Integrated Cancer Research andAnh Thai - aDavid H. Koch Institute for Integrated Cancer Research andJames R. Stone - Massachusetts General HospitalArthur J. Coury - Coury Consulting ServicesRalph Weissleder - Center for Systems BiologyRobert Langer - Massachusetts Institute of TechnologyDaniel G. Anderson - Massachusetts Institute of Technology
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 109(52), pp 21444-21449
- Publisher
- Natl Acad Sciences
- Number of pages
- 6
- Grant note
- U24CA092782 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01DE016516 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) Medtronic, Inc.; Medtronic Juvenile Diabetes Research Foundation MOP119426 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) R31-10071; WCU-2z011-0001696 / Pioneer Research Program R01HL095629 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) DE016516; R01HL096576; U24-CA92782 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000313627700065
- Scopus ID
- 2-s2.0-84871822549
- Other Identifier
- 991019168716304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems