Journal article
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Nature immunology, v 23(12), pp 1777-1787
Dec 2022
PMID: 36316476
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here, we sought to identify a common pre-vaccination signature and mechanisms that could predict the immune response across 13 different vaccines. Analysis of blood transcriptional profiles across studies revealed three distinct pre-vaccination endotypes, characterized by the differential expression of genes associated with a pro-inflammatory response, cell proliferation, and metabolism alterations. Importantly, individuals whose pre-vaccination endotype was enriched in pro-inflammatory response genes known to be downstream of nuclear factor-kappa B showed significantly higher serum antibody responses 1 month after vaccination. This pro-inflammatory pre-vaccination endotype showed gene expression characteristic of the innate activation state triggered by Toll-like receptor ligands or adjuvants. These results demonstrate that wide variations in the transcriptional state of the immune system in humans can be a key determinant of responsiveness to vaccination.
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Details
- Title
- Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
- Creators
- Slim Fourati - Emory UniversityLewis E Tomalin - Icahn School of Medicine at Mount SinaiMatthew P Mulè - University of CambridgeDaniel G Chawla - Yale School of MedicineBram Gerritsen - Yale School of MedicineDmitry Rychkov - University of California, San FranciscoEvan Henrich - Fred Hutchinson Cancer Research Center, Seattle, WA, USAHelen E R Miller - Fred Hutchinson Cancer Research Center, Seattle, WA, USAThomas Hagan - Stanford University School of MedicineJoann Diray-Arce - Harvard Medical SchoolPatrick Dunn - ImmPort Curation Team, NG Health Solutions, Rockville, MD, USAOfer Levy - Harvard Medical SchoolRaphael Gottardo - SIB Swiss Institute of BioinformaticsMinnie M Sarwal - University of California, San FranciscoJohn S Tsang - Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID and Center for Human Immunology (CHI), NIH, Bethesda, MD, USAMayte Suárez-Fariñas - Icahn School of Medicine at Mount SinaiBali Pulendran - Stanford University School of MedicineSteven H Kleinstein - Yale School of MedicineRafick-Pierre Sékaly - Emory UniversityHuman Immunology Project Consortium (HIPC)Elias El Haddad - College of Medicine (2002-)
- Publication Details
- Nature immunology, v 23(12), pp 1777-1787
- Publisher
- Springer Nature
- Grant note
- U19AI128910 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI089992 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19AI090023 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19 AI128949 / NIAID NIH HHS U19AI118608 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19 AI089992 / NIAID NIH HHS U19 AI128914 / NIAID NIH HHS U19AI118610 / U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U19 AI118626 / NIAID NIH HHS U19 AI167903 / NIAID NIH HHS U19 AI128913 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000876917700004
- Scopus ID
- 2-s2.0-85141085346
- Other Identifier
- 991020099366304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology