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Pancreatitis in inflammatory bowel diseases
Journal article   Peer reviewed

Pancreatitis in inflammatory bowel diseases

C S Pitchumoni, Amy Rubin and Kiron Das
Journal of clinical gastroenterology, v 44(4)
Apr 2010
DOI: https://doi.org/10.1097/MCG.0b013e3181cadbe1
PMID: 20087199
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Acute Disease Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Azathioprine - adverse effects Azathioprine - therapeutic use Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Crohn Disease - complications Crohn Disease - drug therapy Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Incidence Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy Mercaptopurine - adverse effects Mercaptopurine - therapeutic use Mesalamine - adverse effects Mesalamine - therapeutic use Pancreatitis - diagnosis Pancreatitis - epidemiology Pancreatitis - etiology Pancreatitis - physiopathology Sulfasalazine - adverse effects Sulfasalazine - therapeutic use
Crohn's disease and ulcerative colitis, together popularly known as inflammatory bowel disease (IBD), are characterized by a number of extraintestinal manifestations. Although infrequent, acute pancreatitis, and less often chronic pancreatitis, may occur as a result of the disease itself or secondary to the medications used in the treatment. The increased incidence of acute pancreatitis in Crohn's disease can be explained based on the high predisposition to cholesterol as well as pigment stones as a result of ileal disease, anatomic abnormalities of the duodenum, immunologic disturbances associated with IBD, and, above all, to the side effects of many medications used in the treatment. Sulfasalazine, 5-aminosalicylic acid, azathioprine, and 6-mercaptopurine are well known to cause acute pancreatitis as a result of a possible idiosyncratic mechanism. Crohn's disease and ulcerative colitis share many clinical manifestations and treatment modalities. Nonspecific elevations of serum pancreatic enzymes in IBD make it difficult to avoid over diagnosis of acute pancreatitis, particularly in patients with Crohn's disease who suffer from abdominal pain often. The IBD-pancreas association is further reflected in many reports of exocrine as well as endocrine pancreatic insufficiency.

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67 citations in Web of Science
80 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Gastroenterology & Hepatology
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