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Journal article
Panel 3: Genomics, precision medicine and targeted therapies
International journal of pediatric otorhinolaryngology, Vol.130(Suppl 1), 109835
Mar 2020
PMID: 32007292
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To review the most recent advances in human and bacterial genomics as applied to pathogenesis and clinical management of otitis media.
PubMed articles published since the last meeting in June 2015 up to June 2019.
A panel of experts in human and bacterial genomics of otitis media was formed. Each panel member reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The panel met at the 20th International Symposium on Recent Advances in Otitis Media in June 2019, discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members.
Trans-disciplinary approaches applying pan-omic technologies to identify human susceptibility to otitis media and to understand microbial population dynamics, patho-adaptation and virulence mechanisms are crucial to the development of novel, personalized therapeutics and prevention strategies for otitis media.
In the future otitis media prevention strategies may be augmented by mucosal immunization, combination vaccines targeting multiple pathogens, and modulation of the middle ear microbiome. Both treatment and vaccination may be tailored to an individual's otitis media phenotype as defined by molecular profiles obtained by using rapidly developing techniques in microbial and host genomics.
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Details
- Title
- Panel 3: Genomics, precision medicine and targeted therapies
- Creators
- Regie Lyn P Santos-Cortez - Department of Otolaryngology, School of Medicine, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO, 80045, USAMahmood F Bhutta - Department of ENT, Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE, UKJoshua P Earl - Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th St., Philadelphia, PA 19102, USALena Hafrén - Department of Otorhinolaryngology, Head & Neck Surgery, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8A, 00290, Helsinki, FinlandMichael Jennings - Institute for Glycomics, Gold Coast Campus, Griffith University, QLD, 4222, AustraliaJoshua C Mell - Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th St., Philadelphia, PA 19102, USAMichael E Pichichero - Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, 1425 Portland Ave., Rochester, NY, 14621, USAAllen F Ryan - Department of Surgery/Otolaryngology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USAHilda Tateossian - Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxford, Didcot, OX11 0RD, UKGarth D Ehrlich - Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th St., Philadelphia, PA 19102, USA
- Publication Details
- International journal of pediatric otorhinolaryngology, Vol.130(Suppl 1), 109835
- Publisher
- Elsevier
- Grant note
- International Society for Otitis Media (ISOM) National Institutes of Health National Institute on Deafness and Other Communication Disorders (https://doi.org/10.13039/100000055)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991014969870004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Otorhinolaryngology
- Pediatrics