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Paralizing activity of the Parawixia bistriata crude venom in termites: a new bioassay
Journal article   Peer reviewed

Paralizing activity of the Parawixia bistriata crude venom in termites: a new bioassay

ACK Fontana, MAR Cairrao, A Colusso, W Santos and J Coutinho-Netto
Toxicon (Oxford), v 38(1), pp 133-138
01 Jan 2000
PMID: 10669018

Abstract

Insecta Parawixia bistriata Termitidae
Spider venoms have high specificity to neuronal elements. Therefore, the use of venom has been important in the characterisation of mammal and insect nervous systems. The evaluation of insect paralysis has been an important tool for distinguishing the biological effects of venom. In this study we describe the paralysing effect of a spider crude venom (Parawixia bistriata) in termites, utilising a new bioassay. The crude venom of P. bistriata caused an irreversible and dose-dependent paralysis in the animals in the following doses: 2.10 super(-5) U: 2.10 super(-4) U; 2.10 super(-3) U; 2.10 super(-2) U and 0.12 U (1 U = 1 gland). This bioassay will allow for easy and direct evaluation of biological effects from different venoms and purified fractions.

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Web of Science research areas
Pharmacology & Pharmacy
Toxicology
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