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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Parametric Imaging Using Subharmonic Signals From Ultrasound Contrast Agents in Patients With Breast Lesions
Journal of ultrasound in medicine, v 30(1), pp 85-92
01 Jan 2011
PMID: 21193708
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Parametric maps showing perfusion of contrast media can be useful tools for characterizing lesions in breast tissue. In this study we show the feasibility of parametric subharmonic imaging (SHI), which allows imaging of a vascular marker (the ultrasound contrast agent) while providing near complete tissue suppression. Digital SHI clips of 16 breast lesions from 14 women were acquired. Patients were scanned using a modified LOGIQ 9 scanner (GE Healthcare, Waukesha, WI) transmitting/receiving at 4.4/2.2 MHz. Using motion-compensated cumulative maximum intensity (CMI) sequences, parametric maps were generated for each lesion showing the time to peak (TTP), estimated perfusion (EP), and area under the time-intensity curve (AUC). Findings were grouped and compared according to biopsy results as benign lesions (n = 12, including 5 fibroadenomas and 3 cysts) and carcinomas (n = 4). For each lesion CMI, TTP, EP, and AUC parametric images were generated. No significant variations were detected with CMI (P=.80), TTP (P=.35), or AUC (P=.65). A statistically significant variation was detected for the average pixel EP (P=.002). Especially, differences were seen between carcinoma and benign lesions (mean +/- SD, 0.10 +/- 0.03 versus 0.05 +/- 0.02 intensity units [IU]/s; P=.0014) and between carcinoma and fibroadenoma (0.10 +/- 0.03 versus 0.04 +/- 0.01 IU/s; P=.0044), whereas differences between carcinomas and cysts were found to be nonsignificant. In conclusion, a parametric imaging method for characterization of breast lesions using the high contrast to tissue signal provided by SHI has been developed. While the preliminary sample size was limited, results show potential for breast lesion characterization based on perfusion flow parameters.
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Details
- Title
- Parametric Imaging Using Subharmonic Signals From Ultrasound Contrast Agents in Patients With Breast Lesions
- Creators
- John R. Eisenbrey - Thomas Jefferson UniversityJaydev K. Dave - Thomas Jefferson UniversityDaniel A. Merton - Thomas Jefferson UniversityJuan P. Palazzo - Thomas Jefferson UniversityAnne L. Hall - GE Healthcare (Netherlands)Flemming Forsberg - Thomas Jefferson University
- Publication Details
- Journal of ultrasound in medicine, v 30(1), pp 85-92
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- DAMD-17-00-1-0464 / US Army Medical Research Material Command; U.S. Army Medical Research & Materiel Command (USAMRMC) CA140338 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01CA140338 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) GE Healthcare; General Electric
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000287009000011
- Scopus ID
- 2-s2.0-78650882289
- Other Identifier
- 991019350669804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging