Journal article
Parental ADHD Status and its Association with Proband ADHD Subtype and Severity
The Journal of pediatrics, v 157(6), pp 995-U191
01 Dec 2010
PMID: 20630538
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To better understand the familial transmission of attention deficit hyperactivity disorder (ADHD), a highly heritable disorder, the effects of paternal and maternal ADHD status on probands' ADHD symptoms and subtypes were investigated.
Study design In 323 trios with ADHD, data from a structured interview and a self-report scale (score of >21) were used to determine ADHD probands' diagnostic status and parental ADHD status, respectively. Parental ADHD status on proband ADHD severity and subtypes was investigated.
Results ADHD criteria were endorsed by 23% of fathers and 27% of mothers, and by at least one parent in 41% of the cases. ADHD severity was higher for children whose parents had ADHD versus those whose parents were without it. Paternal ADHD was associated with an increased likelihood of ADHD combined subtype (odds ratio = 3.56) and a decreased likelihood of the inattentive subtype (odds ratio = 0.34) in male children.
Conclusions Parental ADHD status appears to confer different risks for the severity of hyperactive-impulsive and inattentive symptoms depending on parental sex; however, parental ADHD self-report scale score has low to negligible correlation with proband's ADHD severity. Biparental ADHD does not appear to have an additive or synergistic effect on the proband's ADHD severity. (J Pediatr 2010;157:995-1000).
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Details
- Title
- Parental ADHD Status and its Association with Proband ADHD Subtype and Severity
- Creators
- Toshinobu Takeda - Ryukoku UniversityKory Stotesbery - Thomas Jefferson UniversityThomas Power - Children's Hospital of PhiladelphiaPaul J. Ambrosini - Drexel UniversityWade Berrettini - University of Pennsylvania, Philadelphia PA.Hakon Hakonarson - Children's Hospital of PhiladelphiaJosephine Elia - Children's Hospital of Philadelphia
- Publication Details
- The Journal of pediatrics, v 157(6), pp 995-U191
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- K23MH066275-01 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Center for Applied Genomics at The Children's Hospital of Philadelphia UL1-RR-024134 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) K23MH066275 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) UL1RR024134 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000284307200030
- Scopus ID
- 2-s2.0-78449288427
- Other Identifier
- 991019167760704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics