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Journal article
Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort
Journal of the American Academy of Child and Adolescent Psychiatry, v 58(6), pp 618-627
01 Jun 2019
PMID: 30825496
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT).
Method: The study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time.
Results: Younger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed.
Conclusion: This study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
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Details
- Title
- Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort
- Creators
- Magdalena Janecka - Center for Autism and Related DisordersStefan N. Hansen - Aarhus UniversityAmirhossein Modabbernia - Icahn School of Medicine at Mount SinaiHeidi A. Browne - Icahn School of Medicine at Mount SinaiJoseph D. Buxbaum - Child Health and Development InstituteDiana E. Schendel - Lundbeck FoundationAbraham Reichenberg - Icahn School of Medicine at Mount SinaiErik T. Parner - Aarhus UniversityDorothy E. Grice - Icahn School of Medicine at Mount Sinai
- Publication Details
- Journal of the American Academy of Child and Adolescent Psychiatry, v 58(6), pp 618-627
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Seaver Foundation Stanley Center for Psychiatric Research Mindworks Charitable Lead Trust Mindich Child Health and Development Institute Friedman Brain Institute Lundbeck Foundation Initiative for Integrative Psychiatric Research HD073978; MH097849 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000471838400011
- Scopus ID
- 2-s2.0-85066026517
- Other Identifier
- 991021230001004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics
- Psychiatry
- Psychology, Developmental