Journal article
Parental Occupational Exposures to Chemicals and Incidence of Neuroblastoma in Offspring
American journal of epidemiology, v 154(2), pp 106-114
15 Jul 2001
PMID: 11447042
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To evaluate the effects of parental occupational chemical exposures on incidence of neuroblastoma in offspring, the authors conducted a multicenter case-control study, using detailed exposure information that allowed examination of specific chemicals. Cases were 538 children aged 19 years who were newly diagnosed with confirmed neuroblastoma in 1992–1994 and were registered at any of 139 participating hospitals in the United States and Canada. One age-matched control for each of 504 cases was selected through random digit dialing. Self-reported exposures were reviewed by an industrial hygienist, and improbable exposures were reclassified. Effect estimates were calculated using unconditional logistic regression, adjusting for child's age and maternal demographic factors. Maternal exposures to most chemicals were not associated with neuroblastoma. Paternal exposures to hydrocarbons such as diesel fuel (odds ratio (OR) = 1.5; 95% confidence interval (CI): 0.8, 2.6), lacquer thinner (OR = 3.5; 95% CI: 1.6, 7.8), and turpentine (OR = 10.4; 95% CI: 2.4, 44.8) were associated with an increased incidence of neuroblastoma, as were exposures to wood dust (OR = 1.5; 95% CI: 0.8, 2.8) and solders (OR = 2.6; 95% CI: 0.9, 7.1). The detailed exposure information available in this study has provided additional clues about the role of parental occupation as a risk factor for neuroblastoma.
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Details
- Title
- Parental Occupational Exposures to Chemicals and Incidence of Neuroblastoma in Offspring
- Creators
- Anneclaire J. De Roos - University of North Carolina at Chapel HillAndrew F. Olshan - University of North Carolina at Chapel HillKay Teschke - University of British ColumbiaCharles Poole - University of North Carolina at Chapel HillDavid A. Savitz - University of North Carolina at Chapel HillJulie Blatt - University of North Carolina at Chapel HillMelissa L. Bondy - The University of Texas MD Anderson Cancer CenterBrad H. Pollock - Department of Health Policy and Epidemiology, School of Medicine, University of Florida, Gainesville, FL
- Publication Details
- American journal of epidemiology, v 154(2), pp 106-114
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000169906400002
- Scopus ID
- 2-s2.0-0035879585
- Other Identifier
- 991020112302004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health