Journal article
Paroxysmal Dyskinesias
Seminars in pediatric neurology, v 25(1), pp 75-81
01 Apr 2018
PMID: 29735119
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Paroxysmal dyskinesias (PD) are hyperkinetic movement disorders where patients usually retain consciousness. Paroxysmal dyskinesias can be kinesigenic (PKD), nonkinesigenic (PNKD), and exercise induced (PED). These are usually differentiated from each other based on their phenotypic and genotypic characteristics. Genetic causes of PD are continuing to be discovered. Genes found to be involved in the pathogenesis of PD include MR-1, PRRT2, SLC2A1, and KCNMA1. The differential diagnosis is broad as PDs can mimic psychogenic events, seizure, or other movement disorders. This review also includes secondary causes of PDs, which can range from infections, metabolic, structural malformations to malignancies. Treatment is usually based on the correct identification of type of PD. PKD responds well to antiepileptic medications, whereas PNKD and PED respond to avoidance of triggers and exercise, respectively. In this article, we review the classification, clinical features, genetics, differential diagnosis, and management of PD. (C) 2018 Elsevier Inc. All rights reserved.
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Details
- Title
- Paroxysmal Dyskinesias
- Creators
- Sara McGuire - Drexel Univ, St Christophers Hosp Children, Coll Med, Dept Pediat,Sect Neurol, 160 E Erie Ave, Philadelphia, PA 19134 USASwati Chanchani - Drexel Univ, St Christophers Hosp Children, Coll Med, Dept Pediat,Sect Neurol, 160 E Erie Ave, Philadelphia, PA 19134 USADivya S. Khurana - Drexel University
- Publication Details
- Seminars in pediatric neurology, v 25(1), pp 75-81
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000432731600010
- Scopus ID
- 2-s2.0-85042167583
- Other Identifier
- 991019169668704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics