Journal article
Part 1. Review and meta‐analysis of studies on modulation of longitudinal bone growth and growth plate activity: A macro‐scale perspective
Journal of orthopaedic research, v 39(5), pp 907-918
May 2021
PMID: 33377536
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Growth modulation is an emerging method for treatment of angular skeletal deformities such as adolescent idiopathic scoliosis (AIS). The Hueter‐Volkmann law, by which growth is stimulated in tension and inhibited in compression, is widely understood, and applied in current growth‐modulating interventions such as anterior vertebral body tethering (AVBT) for AIS. However, without quantification of the growth rate effects of tension or compression, the possibility of under‐ or over‐ correction exists. A definitive mechanical growth modulation relationship relating to treatment of such skeletal deformities is yet to exist, and the mechanisms by which growth rate is regulated and altered are not fully defined. Review of current literature demonstrates that longitudinal (i.e., lengthwise) growth rate in multiple animal models depend on load magnitude, anatomical location, and species. Additionally, alterations in growth plate morphology and viability vary by loading parameters such as magnitude, frequency, and whether the load was applied persistently or intermittently. The aggregate findings of the reviewed studies will assist in work towards increasingly precise and clinically successful growth modulation methods. Part 1 of this review focuses on the effects of mechanical loading, species, age, and anatomical location on the macro‐scale alterations in longitudinal bone growth, as well as factors that affect growth plate material properties. Part 2 considers the effects on micro‐scale alterations in growth plate morphology such as zone heights and proportions, chondrocyte viability, and related gene and protein expression.
Metrics
Details
- Title
- Part 1. Review and meta‐analysis of studies on modulation of longitudinal bone growth and growth plate activity: A macro‐scale perspective
- Creators
- Christian R. D'Andrea - Drexel UniversityAusilah Alfraihat - Drexel UniversityAnita Singh - Widener UniversityJason B. Anari - Children's Hospital of PhiladelphiaPatrick J. Cahill - Children's Hospital of PhiladelphiaThomas Schaer - University of PennsylvaniaBrian D. Snyder - Beth Israel Deaconess Medical CenterDawn Elliott - University of DelawareSriram Balasubramanian - Drexel University
- Publication Details
- Journal of orthopaedic research, v 39(5), pp 907-918
- Publisher
- Wiley
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000607374800001
- Scopus ID
- 2-s2.0-85099364202
- Other Identifier
- 991019167649704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics