Journal article
Part 2. Review and meta‐analysis of studies on modulation of longitudinal bone growth and growth plate activity: A micro‐scale perspective
Journal of orthopaedic research, v 39(5), pp 919-928
May 2021
PMID: 33458882
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Macro‐scale changes in longitudinal bone growth resulting from mechanical loading were shown in Part 1 of this review to depend on load magnitude, anatomical location, and species. While no significant effect on longitudinal growth was observed by varying frequency and amplitude of cyclic loading, such variations, in addition to loading duration and species, were shown to affect the morphology, viability, and gene and protein expression within the growth plate. Intermittent compression regimens were shown to preserve or increase growth plate height while stimulating increased chondrocyte presence in the hypertrophic zone relative to persistent and static loading regimens. Gene and protein expressions related to matrix synthesis and degradation, as well as regulation of chondrocyte apoptosis were shown to exhibit magnitude‐, frequency‐, and duration‐dependent responses to loading regimen. Chondrocyte viability was shown to be largely preserved within physiological bounds of magnitude, frequency, amplitude, and duration. Persistent static loading was shown to be associated with overall growth plate height in tension only, reducing it in compression, while affecting growth plate zone heights differently across species and encouraging mineralization relative to intermittent cyclic loading. Lateral loading of the growth plate, as well as microfluidic approaches are relatively understudied, and age, anatomical location, and species effects within these approaches are undefined. Understanding the micro‐scale effects of varied loading regimes can assist in the development of growth modulation methods and device designs optimized for growth plate viability preservation or mineralization stimulation based on patient age and anatomical location.
Metrics
Details
- Title
- Part 2. Review and meta‐analysis of studies on modulation of longitudinal bone growth and growth plate activity: A micro‐scale perspective
- Creators
- Christian R. D'Andrea - Drexel UniversityAusilah Alfraihat - Drexel UniversityAnita Singh - Widener UniversityJason B. Anari - Children's Hospital of PhiladelphiaPatrick J. Cahill - Children's Hospital of PhiladelphiaThomas Schaer - University of PennsylvaniaBrian D. Snyder - Beth Israel Deaconess Medical CenterDawn Elliott - University of DelawareSriram Balasubramanian - Drexel University
- Publication Details
- Journal of orthopaedic research, v 39(5), pp 919-928
- Publisher
- Wiley
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000612783600001
- Scopus ID
- 2-s2.0-85099833926
- Other Identifier
- 991019167326104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Orthopedics