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Journal article
Partial Restoration of Cardiovascular Function by Embryonic Neural Stem Cell Grafts after Complete Spinal Cord Transection
The Journal of neuroscience, Vol.33(43), pp.17138-17149
23 Oct 2013
PMCID: PMC3807033
PMID: 24155317
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore supraspinal control of sympathetic preganglionic neurons (SPNs), we grafted embryonic brainstem-derived neural stem cells (BS-NSCs) or spinal cord-derived neural stem cells (SC-NSCs) expressing green fluorescent protein into the T4 complete transection site of adult rats. Animals with injury alone served as controls. Implanting of BS-NSCs but not SC-NSCs resulted in recovery of basal cardiovascular parameters, whereas both cell grafts alleviated autonomic dysreflexia. Subsequent spinal cord retransection above the graft abolished the recovery of basal hemodynamics and reflexic response. BS-NSC graft-derived catecholaminergic and serotonergic neurons showed remarkable long-distance axon growth and topographical innervation of caudal SPNs. Anterograde tracing indicated growth of medullar axons into stem cell grafts and formation of synapses. Thus, grafted embryonic brainstem-derived neurons can act as functional relays to restore supraspinal regulation of denervated SPNs, thereby contributing to cardiovascular functional improvement.
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Details
- Title
- Partial Restoration of Cardiovascular Function by Embryonic Neural Stem Cell Grafts after Complete Spinal Cord Transection
- Creators
- Shaoping Hou - Drexel UniversityVeronica J. Tom - Drexel UniversityLori Graham - University of California, San DiegoPaul Lu - University of California, San DiegoArmin Blesch - University of California, San Diego
- Publication Details
- The Journal of neuroscience, Vol.33(43), pp.17138-17149
- Publisher
- Soc Neuroscience
- Number of pages
- 12
- Grant note
- 161456 / Craig H. Neilsen Foundation R01NS054883 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) International Spinal Research Trust Veterans Administration; US Department of Veterans Affairs Canadian Spinal Research Organization NS054883 / National Institutes of Health/National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Wings for Life International Foundation for Research in Paraplegia
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991019167824304721
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