Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Patching vs Atropine to Treat Amblyopia in Children Aged 7 to 12 Years A Randomized Trial
Archives of ophthalmology (1960), v 126(12), pp 1634-1642
01 Dec 2008
PMID: 19064841
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To compare patching with atropine eyedrops in the treatment of moderate amblyopia (visual acuity, 20/40-20/100) in children aged 7 to 12 years. In a randomized, multicenter clinical trial, 193 children with amblyopia were assigned to receive weekend atropine or patching of the sound eye 2 hours per day. Masked assessment of visual acuity in the amblyopic eye using the electronic Early Treatment Diabetic Retinopathy Study testing protocol at 17 weeks. At 17 weeks, visual acuity had improved from baseline by an average of 7.6 letters in the atropine group and 8.6 letters in the patching group. The mean difference between groups (patching-atropine) adjusted for baseline acuity was 1.2 letters (ends of complementary 1-sided 95% confidence intervals for noninferiority, -0.7, 3.1 letters). This difference met the prespecified definition for equivalence (confidence interval <5 letters). Visual acuity in the amblyopic eye was 20/25 or better in 15 participants in the atropine group (17%) and 20 in the patching group (24%; difference, 7%; 95% confidence interval, -3% to 17%). Treatment with atropine or patching led to similar degrees of improvement among 7- to 12-year-olds with moderate amblyopia. About 1 in 5 achieved visual acuity of 20/25 or better in the amblyopic eye. Atropine and patching achieve similar results among older children with unilateral amblyopia.
Metrics
Details
- Title
- Patching vs Atropine to Treat Amblyopia in Children Aged 7 to 12 Years A Randomized Trial
- Creators
- Mitchell ScheimanRichard HertleRaymond KrakerRoy BeckEileen BirchJoost FeliusJonathan HolmesJames KundartDavid MorrisonMichael RepkaSusanna TamkinsPediat Eye Dis Investigator Grp
- Publication Details
- Archives of ophthalmology (1960), v 126(12), pp 1634-1642
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000261481700002
- Scopus ID
- 2-s2.0-58149243043
- Other Identifier
- 991021900611104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Ophthalmology