Journal article
Pathogenesis of acute myocardial necrosis in inbred mice infected with coxsackievirus B3
Microbial pathogenesis, v 4(6), pp 417-430
1988
PMID: 2848174
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Abstract
The pathogenesis of myocardial necrosis due to CB3W infection was studied in BALB/c and C3H/HeJ mice. BALB/c mice infected with 5 × 10
4 pfu were found to die of massive hepatic coagulative necrosis before myocardial changes occurred. Reducing the inoculum size to 5 × 10
2 pfu resulted in sublethal hepatic involvement and multifocal myocardial coagulative necrosis by day 7 p.i. In contrast, C3H/HeJ mice survived infection and developed multifocal myocardial coagulative necrosis, but not liver disease following inoculation with as much as 5 × 10
6 pfu of CB3W. As with BALB/c mice infected with 5 × 10
2 pfu, myocardial lesions became apparent in C3H/HeJ mice a few days after peak cardiac virus titer was attained. Minimal inflammatory infiltrate was seen following development of cellular necrosis and was restricted to the areas of virus-induced pathologic change. However, no evidence was found for virus-specific cytotoxic T cell activity or for delayed type hypersensitivity responses. Furthermore, myocardial necrosis in CB3W-infected, T cell-depleted C3H/HeJ mice was as severe as in CB3W-infected, immunocompetent mice. These data have led us to conclude that cardiac lesions were due to virus-induced cytopathology rather than immunopathogenic mechanisms.
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Details
- Title
- Pathogenesis of acute myocardial necrosis in inbred mice infected with coxsackievirus B3
- Creators
- Janet B. Grun - Hahnemann University HospitalMaggie Schultz - Hahnemann University HospitalSydney D. Finkelstein - Hahnemann University HospitalRichard L. Crowell - Hahnemann University HospitalBurton J. Landau - Hahnemann University Hospital
- Publication Details
- Microbial pathogenesis, v 4(6), pp 417-430
- Publisher
- Elsevier India Pvt Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:A1988P643300003
- Scopus ID
- 2-s2.0-0023805639
- Other Identifier
- 991019183970904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Microbiology