Journal article
Pathogenesis of annular lesions: Why a ring presentation?
Clinics in dermatology, v 40(5), pp 420-426
Sep 2022
PMID: 34979269
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Annular lesions represent a distinct morphology which characterizes many well-known derma-tologic conditions. Little is definitively known regarding the pathogenesis of annular lesions, however there a few well-regarded hypotheses. Lesions that clear centrally while enlarging peripherally may result from a local central tissue anergy, or tolerance. The central area in lesions due to dermatophyte infec-tions or subacute cutaneous lupus erythematous may have a central immunity to the antigen that trigged the lesion. The peripheral spread of inflammatory mediators may also contribute to lesions that expand centrifugally. In a highly active immune response, some of the inflammatory mediators may spread to adjacent tissue, which can propagate the inflammatory reaction. The additional hypotheses regarding pathogenesis are disease specific with individual mechanisms having been proposed. This chapter will describe both general and disease specific mechanisms that may contribute to the formation of annular lesions.
Metrics
Details
- Title
- Pathogenesis of annular lesions: Why a ring presentation?
- Creators
- Melissa Hoffman - Drexel Univ, Coll Med, Philadelphia, PA USAMichae Renzi Jr - Cooper University HospitalWarren R. Heymann - Cooper University Hospital
- Publication Details
- Clinics in dermatology, v 40(5), pp 420-426
- Publisher
- Elsevier; NEW YORK
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000961452400003
- Scopus ID
- 2-s2.0-85123680366
- Other Identifier
- 991021861278904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology