Journal article
Pathologic changes induced by phospholipase A 2 isolated from the venom of Collett's snake, Pseudechis colletti: A light and electron microscopic study
Toxicon (Oxford), v 30(2), pp 171-185
1992
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pseudechis colletti is an Australian elapid snake with a range limited to central Queensland, Australia. The venom of this snake, as well as that of several other Australian elapids, has been shown to contain a phospholipase A
2 (PLA
2) which can cause a marked myoglobinuria in mice. Few studies have described the histopathologic and ultrastructural changes that result from myotoxic PLA
2-induced damage. Our investigation demonstrated that the isolated PLA
2 induced myodegeneration and necrosis in myocardium in a dose-related manner, with subsequent myoglobinuria and myoglobinuric nephropathy.
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Details
- Title
- Pathologic changes induced by phospholipase A 2 isolated from the venom of Collett's snake, Pseudechis colletti: A light and electron microscopic study
- Creators
- Scott A. Weinstein - United States Army Medical Research Institute of Infectious DiseasesRonald C. Bell - United States Army Medical Research Institute of Infectious DiseasesCharles R. Brown - United States Army Medical Research Institute of Infectious DiseasesJeffrey E. Fletcher - Hahnemann University HospitalLeonard A. Smith - United States Army Medical Research Institute of Infectious DiseasesLeanice A Smith - Counseling and Family Therapy
- Publication Details
- Toxicon (Oxford), v 30(2), pp 171-185
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy
- Web of Science ID
- WOS:A1992HK58400007
- Scopus ID
- 2-s2.0-0026612143
- Other Identifier
- 991019184035004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology