Journal article
Pathophysiology of complex regional pain syndrome
Expert review of neurotherapeutics, v 6(5), pp 669-681
May 2006
PMID: 16734515
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Complex regional pain syndrome (CRPS) most often follows injury to peripheral nerves or their endings in soft tissue. A combination of prostanoids, kinins and cytokines cause peripheral nociceptive sensitization. In time, the Mg(2+) block of the N-methyl-D-aspartate receptor is removed, pain transmission neurons (PTN) are altered by an influx of Ca(2+) that activates kinases for excitation and phosphatases for depression, activity-dependent plasticity that alters the firing of PTN. In time, these neurons undergo central sensitization that lead to a major physiological change of the autonomic, pain and motor systems. The role of the immune system and the sickness response is becoming clearer as microglia are activated following injury and can induce central sensitization while astrocytes may maintain the process.
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Details
- Title
- Pathophysiology of complex regional pain syndrome
- Creators
- Robert J Schwartzman - Drexel UniversityGuillermo M Alexander - Drexel UniversityJohn Grothusen - Drexel University
- Publication Details
- Expert review of neurotherapeutics, v 6(5), pp 669-681
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Neurology
- Web of Science ID
- WOS:000208702100011
- Scopus ID
- 2-s2.0-33745113527
- Other Identifier
- 991019168206304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pharmacology & Pharmacy