Journal article
Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer
Frontiers in oncology, v 11, pp 744256-744256
04 Oct 2021
PMID: 34671560
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To generate robust patient-derived xenograft (PDX) models for epithelial ovarian cancer (EOC), analyze the resemblance of PDX models to the original tumors, and explore factors affecting engraftment rates, fresh cancer tissues from a consecutive cohort of 158 patients with EOC were collected to construct subcutaneous PDX models. Paired samples of original tumors and PDX tumors were compared at the genome, transcriptome, protein levels, and the platinum-based chemotherapy response was evaluated to ensure the reliability of the PDXs. Univariate and multivariate analyses were used to determine the factors affecting the engraftment rates. The engraftment success rate was 58.23% (92/158) over 3–6 months. The Ki-67 index and receiving neoadjuvant chemotherapy can affect the engraftment rate in primary patients. The PDX models generated in this study were found to retain the histomorphology, protein expression, and genetic alteration patterns of the original tumors, despite the transcriptomic differences observed. Clinically, the PDX models demonstrated a high degree of similarity with patients in terms of the chemotherapy response and could predict prognosis. Thus, the PDX model can be considered a promising and reliable preclinical tool for personalized and precise treatment.
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Details
- Title
- Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer
- Creators
- Jiayu Chen - , , , , , , , , , , , , , ,Ying Jin - , , , , , , , , , , , , , ,Siyi Li - , , , , , , , , , , , , , ,Cui Qiao - , , , , , , , , , , , , , ,Xinxin Peng - , , , , , , , , , , , , , ,Yan Li - , , , , , , , , , , , , , ,Yu Gu - , , , , , , , , , , , , , ,Wei Wang - , , , , , , , , , , , , , ,Yan You - , , , , , , , , , , , , , ,Jie Yin - , , , , , , , , , , , , , ,Ying Shan - , , , , , , , , , , , , , ,Yong-Xue Wang - , , , , , , , , , , , , , ,Meng Qin - , , , , , , , , , , , , , ,Hongyue Li - , , , , , , , , , , , , , ,Yan Cai - , , , , , , , , , , , , , ,Yu Dong - , , , , , , , , , , , , , ,Siying Peng - , , , , , , , , , , , , , ,Lingya Pan - , , , , , , , , , , , , , ,
- Publication Details
- Frontiers in oncology, v 11, pp 744256-744256
- Publisher
- Frontiers Media S.A
- Grant note
- ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000708183100001
- Scopus ID
- 2-s2.0-85117308697
- Other Identifier
- 991020545412404721
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InCites Highlights
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- Web of Science research areas
- Oncology