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Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression
Journal article   Open access   Peer reviewed

Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression

Mark D Sullivan, Wayne J Katon, Joan E Russo, Ellen Frank, James E Barrett, Thomas E Oxman and John W Williams
The Journal of the American Board of Family Practice, v 16(1)
01 Jan 2003
DOI: https://doi.org/10.3122/jabfm.16.1.22
PMID: 12583647
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3122/jabfm.16.1.22View
Published, Version of Record (VoR) Open

Abstract

BACKGROUNDDysthymia and minor depression are common problems in primary care, but it is not known how patient health beliefs shape response to antidepressant treatment of these less severe forms of depression. METHODSThree hundred thirty-three primary care patients with dysthymia or minor depression received at least 4 weeks of paroxetine or placebo in a multicenter, randomized controlled 11-week trial. Patient health beliefs and other characteristics were examined as predictors of treatment adherence and depression remission. RESULTSPatient beliefs were not predictive of adherence to paroxetine or placebo. Patients with less endorsement of biological beliefs about their condition (odds ratio [OR] = 3.40), higher perceived general health (OR = 3.38), meeting criteria for dysthymia (OR = 2.37), and age younger than 60 years (OR = 2.68) were more likely to achieve remission on paroxetine. Patient beliefs did not predict remission on placebo. Those with lower severity of depression symptoms at baseline (OR = 2.70) and women (OR = 2.18) were most likely to achieve remission on placebo. CONCLUSIONSOur results suggest that patients with dysthymia or minor depression are more likely to respond to antidepressant medication if they do not see their depression as a biological illness and see themselves as generally healthy. It is clearly not necessary for patients to believe that their dysthymia or minor depression is biological to respond to antidepressant medication.

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43 citations in Web of Science
50 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Psychiatry
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