Journal article
Patterns of Coordinated Anatomical Change in Human Cortical Development: A Longitudinal Neuroimaging Study of Maturational Coupling
Neuron (Cambridge, Mass.), v 72(5), pp 873-884
08 Dec 2011
PMID: 22153381
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Understanding of human structural brain development has rapidly advanced in recent years, but remains fundamentally "localizational" in nature. Here, we use 376 longitudinally acquired structural brain scans from 108 typically developing adolescents to conduct the first study of coordinated anatomical change within the developing cortex. Correlation in rates of anatomical change was regionally heterogeneous, with fronto-temporal association cortices showing the strongest and most widespread maturational coupling with other cortical areas, and lower-order sensory cortices showing the least. Canonical cortical systems with rich structural and functional interconnectivity showed significantly elevated maturational coupling. Evidence for sexually dimorphic maturational coupling was found within a frontopolar-centered prefrontal system involved in complex decision-making. By providing the first link between cortical connectivity and the coordination of cortical development, we reveal a hitherto unseen property of healthy brain maturation, which may represent a target for neurodeveloprnental disease processes, and a substrate for sexually dimorphic behavior in adolescence.
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Details
- Title
- Patterns of Coordinated Anatomical Change in Human Cortical Development: A Longitudinal Neuroimaging Study of Maturational Coupling
- Creators
- Armin Raznahan - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Jason P. Lerch - University of TorontoNancy Lee - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Dede Greenstein - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Gregory L. Wallace - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Michael Stockman - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Liv Clasen - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Phillip W. Shaw - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.Jay N. Giedd - Child Psychiatry Branch, National Institute of Health, National Institutes of Mental Health, Bethesda, MD 20892, USA.
- Publication Details
- Neuron (Cambridge, Mass.), v 72(5), pp 873-884
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- ZIAMH002794 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) ZIAHG200378 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) Z99 MH999999 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000297971100019
- Scopus ID
- 2-s2.0-83255194563
- Other Identifier
- 991019296818304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences