Journal article
Patterns of Immune Responses to the Host-Encoded GOR and Hepatitis C Virus Core-Derived Epitopes with Relation to Hepatitis C Viremia, Genotypes, and Liver Disease Severity
The Journal of infectious diseases, v 173(2), pp 300-305
01 Feb 1996
PMID: 8568289
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antibody responses to the GOR epitope and hepatitis C virus (HCV) core were investigated in 136 patients with chronic HCV infection. Patient age (P = .011) and necroinflammatory activity (P < .001) were significantly greater in 92 (67.6%) patients with anti-GOR than in 44 (32.4%) patients without anti-GOR. HCV RNA concentration was significantly higher in patients with anti-GOR (P = .031). HCV la or Ib genotypes were also found according to anti-GOR status. GOR and HCV core (amino acids 5–19) antibody responses correlated significantly (rs = .615, P < .001). Anti-HCV core(5–19) was detected in 67 (73%) of 92 patients with and in 14 (32%) of 44 without anti-GOR (P < .001). Patients with concurrent anti-GOR and anti-HCV core(5–19) had significantly greater necroinflammatory activity (P = .003). By multivariate analysis, anti-HCV core(5–19), patient age, and necroinflammatory activity were correlated with anti-GOR response (P < .001). Reactivity to the GOR autoepitope correlates with HCV core response and liver necroinflammatory activity, thus suggesting an immunopathogenic role in chronic hepatitis C.
Metrics
Details
- Title
- Patterns of Immune Responses to the Host-Encoded GOR and Hepatitis C Virus Core-Derived Epitopes with Relation to Hepatitis C Viremia, Genotypes, and Liver Disease Severity
- Creators
- Juan Antonio Quiroga - Hospital Universitario Fundación Jiménez DíazMargarita Pardo - Fundación para el Estudio de las Hepatitis ViralesJulio Martín - Fundación para el Estudio de las Hepatitis ViralesSonia Navas-Martin - Drexel University, Microbiology and ImmunologyVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- The Journal of infectious diseases, v 173(2), pp 300-305
- Publisher
- The University of Chicago Press
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1996TT66500004
- Scopus ID
- 2-s2.0-0030034102
- Other Identifier
- 991022047818904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology