Journal article
Patterns of care for elderly men diagnosed with favorable-risk prostate cancer from 2004 to 2008: a population-based analysis
American journal of clinical oncology, v 36(6), pp 606-611
01 Dec 2013
PMID: 22892435
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
With the widespread use of prostate-specific antigen testing, an increasing number of men are diagnosed with favorable-risk prostate cancer (PC). Recently, emphasis has been placed on active surveillance for selected men with favorable-risk PC to avoid unnecessary treatment for tumors that may be clinically insignificant. We performed a population-based analysis to assess patterns of initial treatment (IT) for a contemporary cohort of elderly men diagnosed with a favorable-risk PC in the United States.
We used the Surveillance, Epidemiology, and End Results database to identify men aged more than or equal to 70 years diagnosed with a favorable-risk PC from 2004 to 2008. Multivariable logistic regression analyses were performed to determine patient, tumor, and socioeconomic factors associated with IT.
A total of 15,108 men more than or equal to 70 years with a favorable-risk PC were identified. Prostatectomy was performed in 2.6% of patients. Fifty-nine percent of patients were recommended to undergo radiation therapy (RT). Among patients 70 to 74 years, 66.45% were recommended to undergo RT. Fifty-nine percent, 36.6%, and 15.8% of patients between 75 and 79, 80 and 84, and more than or equal to 85 years were recommended to receive RT, respectively. Factors significantly associated with IT on multivariable logistic regression analysis included: younger age, white race, Gleason Score 6 (vs.≤5), married marital status, and no history of prior malignancy. We also identified significant geographic variations in patterns of IT.
A large percentage of elderly men diagnosed with favorable-risk PC undergo IT, most commonly with RT. Future research should be performed to identify barriers to patient and physician acceptance of active surveillance.
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Details
- Title
- Patterns of care for elderly men diagnosed with favorable-risk prostate cancer from 2004 to 2008: a population-based analysis
- Creators
- Mark V Mishra - Thomas Jefferson UniversityXinglei ShenRobert B DenColin E ChampEdouard J TrabulsiCostas D LallasLeonard G GomellaAdam P DickerTimothy N Showalter
- Publication Details
- American journal of clinical oncology, v 36(6), pp 606-611
- Publisher
- Lippincott
- Grant note
- P30 CA56036 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000327776800013
- Scopus ID
- 2-s2.0-84892584454
- Other Identifier
- 991021897282904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology