Journal article
Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: Evidence from computer modeling
Hearing research, v 315(100), pp 67-79
01 Sep 2014
PMID: 25019355
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Early neural responses to acoustic signals can be electrically recorded as a series of waves, termed the auditory brainstem response (ABR). The latencies of the ABR waves are important for clinical and neurophysiological evaluations. Using a biophysical model of transmembrane currents along spiral ganglion cells, we show that in human (i) the non-myelinated somatic regions of type I cells, which innervate inner hair cells, predominantly contribute to peak I, (ii) the supra-strong postsynaptic stimulating current (400 pA) and transmembrane currents of the myelinated peripheral axons of type I cells are an order smaller; such postsynaptic currents correspond to the short latencies of a small recordable ABR peak l', (iii) the ABR signal involvement of the central axon of bipolar type I cells is more effective than their peripheral counterpart as the doubled diameter causes larger transmembrane currents and a larger spike dipole-length, (iv) non-myelinated fibers of type II cells which innervate the outer hair cells generate essentially larger transmembrane currents but their ABR contribution is small because of the small ratio type II/type I cells, low firing rates and a short dipole length of spikes propagating slowly in non-myelinated fibers. Using a finite element model of a simplified head, peaks I-n and H (where I-n is the negative peak after peak I) are found to be stationary potentials when volleys of spikes cross the external electrical conductivity barrier at the bone&dura/CSF and at the CSF/brainstem interface whereas peaks I' and I may be generated by strong local transmembrane currents as postsynaptic events at the distal ending and the soma region of type I cells, respectively. All simulated human inter-peak times (I-I', II-I, I-n-I) are close to published data. (C) 2014 The Authors. Published by Elsevier B.V.
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Details
- Title
- Peak I of the human auditory brainstem response results from the somatic regions of type I spiral ganglion cells: Evidence from computer modeling
- Creators
- Frank Rattay - University of ViennaSimon M. Danner - Medical University of Vienna
- Publication Details
- Hearing research, v 315(100), pp 67-79
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- 21848-N13 / Austrian Science Fund; Austrian Science Fund (FWF) P 21848 / Austrian Science Fund (FWF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000341902700008
- Scopus ID
- 2-s2.0-84904861405
- Other Identifier
- 991020099965304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Audiology & Speech-language Pathology
- Neurosciences
- Otorhinolaryngology