Journal article
Pediatric Respiratory Papillomatosis: Prognostic Role of Viral Typing and Cofactors
The Laryngoscope, v 107(7), pp 915-918
Jul 1997
PMID: 9217130
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children with recurrent respiratory papillomatosis vary greatly in their clinical disease course. Many have mild disease with eventual remission while others present with an early aggressive airway obstructive course. This study consisted of 24 pediatric patients whose specimens underwent polymerase chain reaction analysis for cytomegalovirus (CMV), herpes simplex virus (HSV), and human papillomavirus (HPV) type. Nineteen of 24 specimens contained enough DNA for this study. None of the specimens were found to contain DNA from HPV‐16, ‐18, ‐31, ‐33; CMV; or HSV, which contrasts with our previous findings in adults. Ten patients were infected by HPV‐11 and seven of these underwent tracheotomy because of an aggressive tumorigenic clinical course. Nine patients were infected by HPV‐6 alone of whom only two required a tracheotomy (P = 0.05, Fisher's Exact Test). The early airway obstructive course associated with HPV‐11, however, had no bearing on achieving eventual disease remission, with decannulation achieved in eight of nine children.
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Details
- Title
- Pediatric Respiratory Papillomatosis: Prognostic Role of Viral Typing and Cofactors
- Creators
- Frank L RimellDavid L ShoemakerAnna Maria PouJeanne A JordanJ. Christopher PostGarth D Ehrlich
- Publication Details
- The Laryngoscope, v 107(7), pp 915-918
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1997XJ29800015
- Scopus ID
- 2-s2.0-0030802138
- Other Identifier
- 991014969772604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology