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Journal article
Pediatric Selective IgM Immunodeficiency
Clinical & developmental immunology, v 2008, pp 624850-10
01 Jan 2008
PMCID: PMC2587688
PMID: 19043622
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. Results. Forty-nine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was 16.5 +/- 13.8mg/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported. Conclusions. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID. (C) Copyright c 2008 Marc F. Goldstein et al.
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Details
- Title
- Pediatric Selective IgM Immunodeficiency
- Creators
- Marc F. Goldstein - The Asthma Center, Allergic Disease Associates, PC, 205 N. Broad street, Suite 300, Philadelphia, PA 19107, USA. gpike35@asthmacenter.comAlex L. Goldstein - Univ Penn, Wharton Undergrad Div 06, Philadelphia, PA 19104 USAEliot H. Dunsky - Allerg Dis Associates PC, Asthma Ctr, Philadelphia, PA 19107 USADonald J. Dvorin - Allerg Dis Associates PC, Asthma Ctr, Philadelphia, PA 19107 USAGeorge A. Belecanech - Allerg Dis Associates PC, Asthma Ctr, Philadelphia, PA 19107 USAKfir Shamir - Med Coll Penn & Hahnemann Univ, Dept Med, Philadelphia, PA 19102 USA
- Publication Details
- Clinical & developmental immunology, v 2008, pp 624850-10
- Publisher
- Hindawi Publishing Group
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine; Obstetrics and Gynecology
- Web of Science ID
- WOS:000261570700001
- Scopus ID
- 2-s2.0-57449095166
- Other Identifier
- 991019168358604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology