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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Peeling back the layers of locomotor control in the spinal cord
Current opinion in neurobiology, v 33
01 Aug 2015
PMID: 25820136
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vertebrate locomotion is executed by networks of neurons within the spinal cord. Here, we describe recent advances in our understanding of spinal locomotor control provided by work using optical and genetic approaches in mice and zebrafish. In particular, we highlight common observations that demonstrate simplification of limb and axial motor pool coordination by spinal network modularity, differences in the deployment of spinal modules at increasing speeds of locomotion, and functional hierarchies in the regulation of locomotor rhythm and pattern. We also discuss the promise of intersectional genetic strategies for better resolution of network components and connectivity, which should help us continue to close the gap between theory and function.
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Details
- Title
- Peeling back the layers of locomotor control in the spinal cord
- Creators
- David L. McLean - Northwestern UniversityKimberly J. Dougherty - Drexel University
- Publication Details
- Current opinion in neurobiology, v 33
- Publisher
- Current Biology Ltd
- Number of pages
- 8
- Grant note
- NS067299 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS067299 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000359960800010
- Scopus ID
- 2-s2.0-84925665187
- Other Identifier
- 991019168457704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences