Logo image
Peering through the mist: systematic review of what the chemistry of contaminants in electronic cigarettes tells us about health risks
Journal article   Open access   Peer reviewed

Peering through the mist: systematic review of what the chemistry of contaminants in electronic cigarettes tells us about health risks

Igor Burstyn
BMC public health, v 14(1), pp 18-18
09 Jan 2014
PMID: 24406205
url
https://doi.org/10.1186/1471-2458-14-18View
Published, Version of Record (VoR) Open

Abstract

Glycerol - analysis Risk Assessment Humans Propylene Glycol - analysis Volatile Organic Compounds - analysis Electronic Nicotine Delivery Systems - statistics & numerical data Risk Aerosols - chemistry Inhalation Exposure - analysis Hydrocarbons - analysis Nicotine - adverse effects Nicotine - analysis Drug Contamination - statistics & numerical data Hydrocarbons - chemistry Threshold Limit Values Hydrocarbons - adverse effects Glycerol - chemistry Volatile Organic Compounds - chemistry Propylene Glycol - chemistry
Electronic cigarettes (e-cigarettes) are generally recognized as a safer alternative to combusted tobacco products, but there are conflicting claims about the degree to which these products warrant concern for the health of the vapers (e-cigarette users). This paper reviews available data on chemistry of aerosols and liquids of electronic cigarettes and compares modeled exposure of vapers with occupational safety standards. Both peer-reviewed and "grey" literature were accessed and more than 9,000 observations of highly variable quality were extracted. Comparisons to the most universally recognized workplace exposure standards, Threshold Limit Values (TLVs), were conducted under "worst case" assumptions about both chemical content of aerosol and liquids as well as behavior of vapers. There was no evidence of potential for exposures of e-cigarette users to contaminants that are associated with risk to health at a level that would warrant attention if it were an involuntary workplace exposures. The vast majority of predicted exposures are < <1% of TLV. Predicted exposures to acrolein and formaldehyde are typically <5% TLV. Considering exposure to the aerosol as a mixture of contaminants did not indicate that exceeding half of TLV for mixtures was plausible. Only exposures to the declared major ingredients--propylene glycol and glycerin--warrant attention because of precautionary nature of TLVs for exposures to hydrocarbons with no established toxicity. Current state of knowledge about chemistry of liquids and aerosols associated with electronic cigarettes indicates that there is no evidence that vaping produces inhalable exposures to contaminants of the aerosol that would warrant health concerns by the standards that are used to ensure safety of workplaces. However, the aerosol generated during vaping as a whole (contaminants plus declared ingredients) creates personal exposures that would justify surveillance of health among exposed persons in conjunction with investigation of means to keep any adverse health effects as low as reasonably achievable. Exposures of bystanders are likely to be orders of magnitude less, and thus pose no apparent concern.

Metrics

19 Record Views
156 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Public, Environmental & Occupational Health
Logo image