Journal article
Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B
Journal of viral hepatitis, v 32(3), e70010
Mar 2025
PMID: 39953814
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Medication nonadherence among patients with chronic hepatitis B (CHB) can lead to severe liver disease progression, including liver cirrhosis and hepatocellular carcinoma (HCC). Yet the factors that influence adherence in high-risk groups, like Korean Americans, remain unclear. Thus, this study explored the psychosocial and clinical factors affecting medication adherence in CHB patients. A cohort of 365 Korean American patients with CHB from two clinics in Philadelphia and Los Angeles was studied. The 8-item Morisky Medication Adherence Scale (MMAS-8) gauged their adherence to antiviral medication. Using descriptive and multivariable logistic regression analyses, we identified factors associated with MMAS-8 scores. Of the participants, 78% were undergoing antiviral therapy, with over two-thirds (69%) reporting medium to high adherence levels. The multivariable logistic regression analysis revealed that age, knowledge of sequalae of CHB, perceived HBV stigma and possession of pharmacy plan were associated with medication adherence. Older participants had higher medication adherence than younger. High knowledge of sequalae of CHB and low perceived HBV stigma were associated with higher medication adherence. Having pharmacy plans was also associated with higher medication adherence to antiviral therapy. These findings highlight the critical role of person-related factors (e.g., knowledge and stigma) and healthcare factors in medication adherence. Future research should focus on developing targeted educational interventions focusing on personal factors to improve medication adherence among Korean American patients with CHB.
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Details
- Title
- Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B
- Creators
- Hee-Soon Juon (Corresponding Author) - Thomas Jefferson UniversityDaniel Yang - Thomas Jefferson UniversityCindy Xin Fang - Thomas Jefferson UniversityHie-Won Hann - Thomas Jefferson University HospitalHo Bae - Asian Health CoalitionMimi Chang - Asian Health CoalitionAnn C Klassen - Drexel University
- Publication Details
- Journal of viral hepatitis, v 32(3), e70010
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- NIDDK NIH HHS R01DK125541 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Community Health and Prevention
- Web of Science ID
- WOS:001421408800001
- Scopus ID
- 2-s2.0-85218820391
- Other Identifier
- 991022028225404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology
- Infectious Diseases
- Virology