Journal article
Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
Journal of the American College of Cardiology, v 72(16), pp 1898-1909
16 Oct 2018
PMID: 30309466
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In patients with disabling symptoms caused by hypertrophic obstructive cardiomyopathy (HOCM), echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) could be a less invasive treatment option.
This study aimed to investigate the safety and efficacy of the PIMSRA for left ventricular outflow tract (LVOT) gradient reduction in HOCM.
The study enrolled 15 patients with HOCM. These patients underwent electrocardiography, imaging, and blood biochemistry examination over 6 months of follow-up.
At 6 months of follow-up, patients showed significant reductions in peak LVOT gradients (resting gradient: from 88.00 [66.00] mm Hg to 11.00 [6.00] mm Hg; p = 0.001; stress-induced gradient: from 117.00 [81.00] mm Hg to 25.00 [20.00] mm Hg; p = 0.005) and interventricular septum (IVS) thickness (anterior IVS: from 25.00 [21.00] mm to 14.00 [12.00] mm; p = 0.001; posterior IVS: from 24.00 [21.00] mm to 14.00 [11.50] mm; p = 0.001). The reductions in IVS thickness and LVOT gradients were associated with improvement in New York Heart Association functional classification (from 3.00 [2.00] to 1.00 [1.00]; p < 0.001), total exercise time (from 6.00 [5.50] min to 9.00 [8.00] min; p = 0.007), and pro B-type natriuretic peptide levels (from 924.00 [370.45] pg/ml to 137.45 [75.73] pg/ml; p = 0.028). No patient had bundle branch block or complete heart block.
PIMSRA is a safe and effective treatment approach for severe, symptomatic HOCM and results in sustained improvement in exercise capacity, persistent reduction in LVOT gradient, and sustained improvement in cardiac function.
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Details
- Title
- Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
- Creators
- Liwen Liu - Xijing HospitalJing Li - Xijing HospitalLei Zuo - Xijing HospitalJinzhou Zhang - Xijing HospitalMengyao Zhou - Xijing HospitalBo Xu - Xijing HospitalRebeccca T. Hahn - Columbia University Medical CenterMartin B. Leon - Columbia University Medical CenterDavid H. Hsi - Stamford HospitalJunbo Ge - Shanghai Medical College of Fudan UniversityXiaodong Zhou - Xijing HospitalJun Zhang - Xijing HospitalShuping Ge - St. Christopher's Hospital for ChildrenLize Xiong - Xijing Hospital
- Publication Details
- Journal of the American College of Cardiology, v 72(16), pp 1898-1909
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000446588400003
- Scopus ID
- 2-s2.0-85054022080
- Other Identifier
- 991019167807504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems