Journal article
Perfluorinated acids and hypothyroxinemia in pregnant women
Environmental research, v 111(4), pp 559-564
2011
PMID: 21310403
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Perfluorinated acids (PFAs) are prominent and widespread contaminants of human blood. In animal studies there is evidence that suggests certain PFAs can disrupt thyroid hormone homeostasis. A commonly reported condition in exposed animals is hypothyroxinemia, whereby serum free thyroxine (fT4) is decreased despite normal thyroid stimulating hormone (TSH) concentrations. We designed an individually matched case-control study to investigate whether exposure to perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) was associated with hypothyroxinemia in pregnant women from Edmonton, Alberta, Canada, in 2005–2006, who underwent a “triple screen” blood test at 15–20 weeks gestation as part of ante-natal care. Thyroid hormones, fT4 and TSH, were measured in serum from 974 women, and from these we measured PFAs in the sera of 96 hypothyroxinemic cases (normal TSH, the lowest 10th percentile of fT4) and 175 controls (normal TSH, fT4 between the 50th and 90th percentiles) matched on age and referring physician. Analyses by conditional logistic regression indicated that the concentrations of PFAs in this population were not associated with hypothyroxinemia among pregnant women. The current findings do not support a causal link between PFA exposure and maternal hypothyroxinemia in the studied population.
► We examined whether perfluorinated acids caused hypothyroxinemia in pregnant women. ► Exposure was assessed as serum concentrations of perfluorinated acids. ► Pregnant women with hypothyroxinemia and normal thyroid were compared. ► Hypothyroxinemia in pregnancy was not related to exposure to perfluorinated acids.
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Details
- Title
- Perfluorinated acids and hypothyroxinemia in pregnant women
- Creators
- Emily Chan - Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, CanadaIgor Burstyn - Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, CanadaNicola Cherry - Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, CanadaFiona Bamforth - Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, CanadaJonathan W Martin - Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
- Publication Details
- Environmental research, v 111(4), pp 559-564
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000290141600012
- Scopus ID
- 2-s2.0-79955105245
- Other Identifier
- 991014877877404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health