Journal article
Perinatal High Fat Diet Increases Inhibition of Dorsal Motor Nucleus of the Vagus Neurons Regulating Gastric Functions
Neurogastroenterology and motility, Vol.30(1), pn/a
Jan 2018
PMID: 28762595
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Perinatal high fat diet exposure (PNHFD) increases tonic inhibitory inputs to gastric-projecting DMV neurons, increasing DMV neuronal inhibition and vagal efferent inhibition of gastric tone and motility. While the mechanisms responsible for this increased synaptic inhibition remain unknown, they do not appear to involve an increased number of function of GABA receptors, GABA uptake, or neuroglial modulation of synaptic strength. Alterations in brainstem neurocircuit development may dysregulate vagal control of gastric motor functions which, in turn, may be at least partially responsible for the increased propensity of PNHFD-exposed offspring to develop obesity and related comorbidities in later life.
Metrics
2 Record Views
Details
- Title
- Perinatal High Fat Diet Increases Inhibition of Dorsal Motor Nucleus of the Vagus Neurons Regulating Gastric Functions
- Creators
- Caitlin A. McMenamin - Pennsylvania State UniversityR. Alberto Travagli - Penn State Milton S. Hershey Medical CenterCaitlin A Howe - Drexel University, Neurobiology and AnatomyKirsteen N. Browning - Penn State Milton S. Hershey Medical Center
- Publication Details
- Neurogastroenterology and motility, Vol.30(1), pn/a
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000418414300002
- Scopus ID
- 2-s2.0-85026521698
- Other Identifier
- 991022058836704721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Web of Science research areas
- Clinical Neurology
- Gastroenterology & Hepatology
- Neurosciences