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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Perinatal Stroke and the Risk of Developing Childhood Epilepsy
The Journal of pediatrics, v 151(4), pp 409-413.e2
01 Oct 2007
PMID: 17889079
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To describe the prevalence of epilepsy after 6 months of age in children with perinatal stroke and examine whether perinatal data predict epilepsy onset and resolution.
A retrospective review of 64 children with perinatal stroke. In children with at least 6 months of follow-up data, Kaplan-Meier curves, univariate log-rank tests, and Cox proportional hazards models were used to examine predictors of time to development of seizures, and time to resolution of seizures in children with epilepsy. The association of risk factors with the presence of epilepsy at any time after 6 months of age was examined using Fisher’s exact test.
Forty-one of the 61 children with at least 6 months of follow-up data (67%) had epilepsy between 6 months of age and last follow-up, but in 13 of 41, seizures eventually resolved and anticonvulsants were discontinued. Infarct on prenatal ultrasonography (
P = .0065) and family history of epilepsy (
P = .0093) were significantly associated with time to development of seizures after 6 months of age in the univariate analysis. No assessed variables were associated with time to resolution of epilepsy or with the presence of epilepsy after 6 months of age.
Childhood epilepsy is frequent after perinatal stroke. Evidence of infarction on prenatal ultrasonography and a family history of epilepsy predict earlier onset of active seizures.
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Details
- Title
- Perinatal Stroke and the Risk of Developing Childhood Epilepsy
- Creators
- Meredith R. Golomb - Indiana University – Purdue University IndianapolisBhuwan P. Garg - Indiana University – Purdue University IndianapolisKaren S. Carvalho - Indiana University – Purdue University IndianapolisCynthia S. Johnson - Indiana University – Purdue University IndianapolisLinda S. Williams - Indiana University – Purdue University Indianapolis
- Publication Details
- The Journal of pediatrics, v 151(4), pp 409-413.e2
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000249966800021
- Scopus ID
- 2-s2.0-34548663345
- Other Identifier
- 991021448188904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics