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Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course
Journal article   Open access   Peer reviewed

Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course

Christopher Faulk, Amanda Barks, Brisa N Sánchez, Zhenzhen Zhang, Olivia S Anderson, Karen E Peterson and Dana C Dolinoy
PloS one, v 9(8), pp e104273-e104273
2014
DOI: https://doi.org/10.1371/journal.pone.0104273
PMID: 25105421
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104273&type=printableView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1371/journal.pone.0104273View
Published, Version of Record (VoR) Open

Abstract

Age Factors Animals Area Under Curve Blood Glucose - drug effects Body Composition - drug effects Body Weight - drug effects Dose-Response Relationship, Drug Eating - drug effects Energy Metabolism - drug effects Female Glucose Tolerance Test Lead - analysis Lead - toxicity Linear Models Male Maternal Exposure - adverse effects Mice Milk - adverse effects Milk - chemistry Phenotype Pregnancy Prenatal Exposure Delayed Effects - physiopathology Sex Factors
Developmental lead (Pb) exposure has been associated with lower body weight in human infants and late onset obesity in mice. We determined the association of perinatal Pb exposure in mice with changes in obesity-related phenotypes into adulthood. Mice underwent exposure via maternal drinking water supplemented with 0 (control), 2.1 (low), 16 (medium), or 32 (high) ppm Pb-acetate two weeks prior to mating through lactation. Offspring were phenotyped at ages 3, 6, and 9 months for energy expenditure, spontaneous activity, food intake, body weight, body composition, and at age 10 months for glucose tolerance. Data analyses were stratified by sex and adjusted for litter effects. Exposed females and males exhibited increased energy expenditure as compared to controls (p<0.0001 for both). In females, horizontal activity differed significantly from controls (p = 0.02) over the life-course. Overall, food intake increased in exposed females and males (p<0.0008 and p<0.0001, respectively) with significant linear trends at 9 months in females (p = 0.01) and 6 months in males (p<0.01). Body weight was significantly increased in males at the medium and high exposures (p = 0.001 and p = 0.006). Total body fat differed among exposed females and males (p<0.0001 and p<0.0001, respectively). Insulin response was significantly increased in medium exposure males (p<0.05). Perinatal Pb exposure at blood lead levels between 4.1 µg/dL and 32 µg/dL is associated with increased food intake, body weight, total body fat, energy expenditure, activity, and insulin response in mice. Physiological effects of developmental Pb exposure persist and vary according to sex and age.

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Collaboration types
Domestic collaboration
Web of Science research areas
Toxicology
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