Perinatal systemic inflammatory response syndrome and retinopathy of prematurity

Beena G Sood; Ashima Madan; Shampa Saha; Diana Schendel; Poul Thorsen; Kristin Skogstrand; David Hougaard; Seetha Shankaran; Wally Carlo; NICHD neonatal research network

doi:10.1203/PDR.0b013e3181d01a36

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Perinatal systemic inflammatory response syndrome and retinopathy of prematurity

Journal article

Open access

Peer reviewed

Perinatal systemic inflammatory response syndrome and retinopathy of prematurity

Beena G Sood, Ashima Madan, Shampa Saha, Diana Schendel, Poul Thorsen, Kristin Skogstrand, David Hougaard, Seetha Shankaran, Wally Carlo and NICHD neonatal research network

Pediatric research, v 67(4), pp 394-400

01 Apr 2010

DOI: https://doi.org/10.1203/PDR.0b013e3181d01a36

PMID: 20032809

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Cytokines - blood

Cytokines - immunology

Female

Gestational Age

Humans

Infant

Infant, Newborn

Inflammation - blood

Inflammation - complications

Inflammation - immunology

Male

Pregnancy

Retinopathy of Prematurity - blood

Retinopathy of Prematurity - etiology

Retinopathy of Prematurity - immunology

Fetal and neonatal inflammation is associated with several morbidities of prematurity. Its relationship to retinopathy of prematurity (ROP) has not been investigated. Our objective was to determine the relationship between cytokine levels and ROP in the first 3 postnatal wks. Data for this study were derived from the NICHD Cytokine Study. Dried blood spots (DBS) were obtained from infants <1000 g on days 0-1, 3 +/- 1, 7 +/- 2, 14 +/- 3, and 21 +/- 3. Infants were classified into three groups-no, mild, and severe ROP. Multiplex Luminex assay was used to quantify 20 cytokines. Temporal profiles of cytokines were evaluated using mixed-effects models after controlling for covariates. Of 1074 infants enrolled, 890 were examined for ROP and 877 included in the analysis. ROP was associated with several clinical characteristics on unadjusted analyses. Eight cytokines remained significantly different across ROP groups in adjusted analyses. IL-6 and IL-17 showed significant effects in early time periods (D0-3); TGF-beta, brain-derived neurotrophic factor (BDNF), and regulated on activation, normal T cell expressed and secreted (RANTES) in later time periods (D7-21) and IL-18, C-reactive protein (CRP), and neurotrophin-4 (NT-4) in both early and later time periods. We conclude that perinatal inflammation may be involved in the pathogenesis of ROP.

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143 citations in Web of Science

155 citations in Scopus

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Title: Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
Creators: Beena G Sood - Wayne State University
Ashima Madan - Stanford University
Shampa Saha
Diana Schendel
Poul Thorsen - Aarhus University
Kristin Skogstrand - Statens Serum Institut
David Hougaard - Statens Serum Institut
Seetha Shankaran - Wayne State University
Wally Carlo - University of Alabama at Birmingham
NICHD neonatal research network
Publication Details: Pediatric research, v 67(4), pp 394-400
Grant note: U10 HD027904-15 / NICHD NIH HHS U10 HD27856 / NICHD NIH HHS U10 HD021385-20S2 / NICHD NIH HHS M01 RR997 / NCRR NIH HHS U10 HD040498-05 / NICHD NIH HHS M01 RR16587 / NCRR NIH HHS U10 HD027871 / NICHD NIH HHS U10 HD27880 / NICHD NIH HHS M01 RR008084 / NCRR NIH HHS M01 RR016587 / NCRR NIH HHS UG1 HD027880 / NICHD NIH HHS U10 HD040498 / NICHD NIH HHS U10 HD27904 / NICHD NIH HHS U10 HD021364-24 / NICHD NIH HHS U10 HD021373 / NICHD NIH HHS U10 HD040492 / NICHD NIH HHS M01 RR39 / NCRR NIH HHS M01 RR000070-41 / NCRR NIH HHS M01 RR32 / NCRR NIH HHS U10 HD027851-18 / NICHD NIH HHS U10 HD027881-10 / NICHD NIH HHS M01 RR7122 / NCRR NIH HHS U10 HD034216-14 / NICHD NIH HHS U10 HD27853 / NICHD NIH HHS U01HD36790 / NICHD NIH HHS M01 RR70 / NCRR NIH HHS U10 HD040689 / NICHD NIH HHS U10 HD027904 / NICHD NIH HHS M01 RR8084 / NCRR NIH HHS U10 HD40498 / NICHD NIH HHS UL1 TR000454 / NCATS NIH HHS U10 HD040492-09 / NICHD NIH HHS U10 HD027853-15 / NICHD NIH HHS Y1-HD-5000-01 / NICHD NIH HHS U10 HD40492 / NICHD NIH HHS M01 RR007122 / NCRR NIH HHS U10 HD021385 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS U10 HD027880-18 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS U10HD27881 / NICHD NIH HHS M01 RR80 / NCRR NIH HHS M01 RR000030-45 / NCRR NIH HHS U10 HD34216 / NICHD NIH HHS U10 HD27851 / NICHD NIH HHS M01 RR006022 / NCRR NIH HHS U10 HD21397 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U10 HD21415 / NICHD NIH HHS U01 HD036790-10 / NICHD NIH HHS U10 HD21364 / NICHD NIH HHS U10 HD021415-15S2 / NICHD NIH HHS U10 HD021373-25 / NICHD NIH HHS K23 HD041423 / NICHD NIH HHS U10 HD027856 / NICHD NIH HHS U10 HD27871 / NICHD NIH HHS U10 HD027880 / NICHD NIH HHS U10 HD027853 / NICHD NIH HHS U10 HD027871-19 / NICHD NIH HHS U10 HD40689 / NICHD NIH HHS U10 HD021364 / NICHD NIH HHS M01 RR000032-43 / NCRR NIH HHS U10 HD027851 / NICHD NIH HHS U10 HD40461 / NICHD NIH HHS U10 HD21385 / NICHD NIH HHS M01 RR633 / NCRR NIH HHS M01 RR750 / NCRR NIH HHS U10 HD034216 / NICHD NIH HHS M01 RR6022 / NCRR NIH HHS U10 HD021397-20S2 / NICHD NIH HHS U10 HD040461-05S1 / NICHD NIH HHS U01 HD036790 / NICHD NIH HHS U10 HD21373 / NICHD NIH HHS M01 RR016587-01 / NCRR NIH HHS M01 RR30 / NCRR NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: A.J. Drexel Autism Institute
Web of Science ID: WOS:000275881600011
Scopus ID: 2-s2.0-77949563283
Other Identifier: 991021229885104721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Pediatrics

Perinatal systemic inflammatory response syndrome and retinopathy of prematurity

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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