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Journal article
Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
Arthritis & rheumatology (Hoboken, N.J.), v 72(1), pp 67-77
Jan 2020
PMID: 31390162
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients.
Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate.
Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy.
PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.
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Details
- Title
- Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
- Creators
- John G Hanly - Queen Elizabeth II Health Sciences CentreQiuju Li - University of CambridgeLi Su - University of CambridgeMurray B Urowitz - Toronto Western HospitalCaroline Gordon - University of BirminghamSang-Cheol Bae - Hanyang University Seoul HospitalJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJorge Sanchez-Guerrero - Toronto Western HospitalSasha Bernatsky - McGill UniversityAnn E Clarke - University of CalgaryDaniel J Wallace - Cedars-Sinai Medical CenterDavid A Isenberg - University College LondonAnisur Rahman - University College LondonJoan T Merrill - Oklahoma Medical Research FoundationPaul R Fortin - Université LavalDafna D Gladman - Toronto Western HospitalIan N Bruce - NIHR Manchester Biomedical Research CentreMichelle Petri - Johns Hopkins MedicineEllen M Ginzler - SUNY Downstate Health Sciences UniversityM A Dooley - University of North Carolina at Chapel HillKristjan Steinsson - Reykjavík UniversityRosalind Ramsey-Goldman - Northwestern UniversityAsad A Zoma - Hairmyres HospitalSusan Manzi - Allegheny Health NetworkOla Nived - Lund UniversityAndreas Jonsen - Lund UniversityMunther A Khamashta - St Thomas' HospitalGraciela S Alarcón - University of Alabama at BirminghamElisabet Svenungsson - Karolinska University HospitalRonald F van Vollenhoven - Amsterdam University Medical CentersCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchGuillermo Ruiz-Irastorza - Hospital de CrucesManuel Ramos-Casals - Consorci Institut D'Investigacions Biomediques August Pi I SunyerS Sam Lim - Emory UniversityMurat Inanc - Istanbul UniversityKenneth C Kalunian - University of California, San DiegoSoren Jacobsen - Copenhagen University HospitalChristine A Peschken - University of ManitobaDiane L Kamen - Medical University of South CarolinaAnca Askanase - New York University Langone Orthopedic HospitalChris Theriault - Queen Elizabeth II Health Sciences CentreVernon Farewell - University of Cambridge
- Publication Details
- Arthritis & rheumatology (Hoboken, N.J.), v 72(1), pp 67-77
- Publisher
- Wiley
- Grant note
- P30 AR072579 / NIAMS NIH HHS M01 RR000046 / NCRR NIH HHS UL1 TR000150 / NCATS NIH HHS Department of Health Wellcome Trust UL1 TR001422 / NCATS NIH HHS UL1 RR025741 / NCRR NIH HHS MC_UU_00002/11 / Medical Research Council P60 AR048098 / NIAMS NIH HHS P60 AR064464 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000499144100001
- Scopus ID
- 2-s2.0-85075747200
- Other Identifier
- 991021933904804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology