Journal article
Peripheral nerve grafts support regeneration after spinal cord injury
Neurotherapeutics, v 8(2)
Apr 2011
PMID: 21360238
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Traumatic insults to the spinal cord induce both immediate mechanical damage and subsequent tissue degeneration leading to a substantial physiological, biochemical, and functional reorganization of the spinal cord. Various spinal cord injury (SCI) models have shown the adaptive potential of the spinal cord and its limitations in the case of total or partial absence of supraspinal influence. Meaningful recovery of function after SCI will most likely result from a combination of therapeutic strategies, including neural tissue transplants, exogenous neurotrophic factors, elimination of inhibitory molecules, functional sensorimotor training, and/or electrical stimulation of paralyzed muscles or spinal circuits. Peripheral nerve grafts provide a growth-permissive substratum and local neurotrophic factors to enhance the regenerative effort of axotomized neurons when grafted into the site of injury. Regenerating axons can be directed via the peripheral nerve graft toward an appropriate target, but they fail to extend beyond the distal graft-host interface because of the deposition of growth inhibitors at the site of SCI. One method to facilitate the emergence of axons from a graft into the spinal cord is to digest the chondroitin sulfate proteoglycans that are associated with a glial scar. Importantly, regenerating axons that do exit the graft are capable of forming functional synaptic contacts. These results have been demonstrated in acute injury models in rats and cats and after a chronic injury in rats and have important implications for our continuing efforts to promote structural and functional repair after SCI.
Metrics
Details
- Title
- Peripheral nerve grafts support regeneration after spinal cord injury
- Creators
- Marie-Pascale Côté - Department of Neurobiology and Anatomy, Spinal Cord Research Center, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USAArthi A AminVeronica J TomJohn D Houle
- Publication Details
- Neurotherapeutics, v 8(2)
- Publisher
- Springer Nature; United States
- Grant note
- R37 NS026380 / NINDS NIH HHS R01 NS026380 / NINDS NIH HHS NS026380 / NINDS NIH HHS P01 NS055976 / NINDS NIH HHS NS055976 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000289566900015
- Scopus ID
- 2-s2.0-79955055970
- Other Identifier
- 991014877753304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy