Journal article
Peripheral serotonin is an incomplete signal for eliciting satiety in sham-feeding rats
Pharmacology, biochemistry and behavior, v 43(3), pp 847-854
Nov 1992
PMID: 1448479
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Peripheral administration of serotonin [5-hydroxytryptamine (5-HT)] to rats equipped with gastric cannulae reduced their 30-min consumption of sweetened milk after overnight deprivation whether the cannulae were closed (real feeding) or open (sham feeding). The anorectic action of 5-HT (1.6, 4.0, and 10.0 mumol/kg, IP) in sham feeding was dose-related, rapid in onset, and persisted during the 30-min testing session. However, 5-HT failed to elicit resting--the terminal behavioral phase of satiety--in sham-feeding rats. Direct comparison of the effects of 4.0 mumol/kg 5-HT under both feeding conditions established that this dose promoted resting only when rats fed with their cannulae closed. The actions of 5-HT on feeding and resting were behaviorally selective because serotonergic treatment did not retard the beginning of feeding, alter sham drinking of water, or reduce investigation by food-deprived rats of a novel object in an open field. Together, the results suggest that 5-HT exerts separate actions to inhibit feeding and accelerate the process of satiation as marked by resting. However, peripheral 5-HT is inadequate as a signal for modulating satiety in the absence of postingestive stimuli.
Metrics
Details
- Title
- Peripheral serotonin is an incomplete signal for eliciting satiety in sham-feeding rats
- Creators
- K J Simansky - Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129J JakubowF C SiskA H VaidyaK Eberle-Wang
- Publication Details
- Pharmacology, biochemistry and behavior, v 43(3), pp 847-854
- Publisher
- Elsevier; United States
- Grant note
- MH-41987 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1992JW33400026
- Scopus ID
- 2-s2.0-0026468255
- Other Identifier
- 991014878313604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences
- Pharmacology & Pharmacy