Journal article
Peripherally administered alpha-methyl-5-hydroxy-tryptamine and 5-carboxamidotryptamine reduce food intake via different mechanisms in rats
Behavioural pharmacology, v 1(3)
01 Jan 1989
PMID: 11224035
Abstract
Peripherally administering the serotonin (5-HT) analogs, alpha-methyl-5-hydroxytryptamine (alpha-Me-5-HT) and 5-carboxamidotryptamine (5-CT), reduced milk consumption by food-deprived rats. 5-CT decreased milk intake 100-fold more potently than alpha-Me-5-HT (ID(50)'s =.06 and 5.6µmol/kg, respectively). 5-CT also elicited drinking but alpha-Me-5-HT did not. The nonselective 5-HT antagonist, methysergide, blocked the anorectic actions of each agonist. By contrast, the 5-HT(2) antagonist, ketanserin, and the peripheral 5-HT(2) antagonist, xylamidine, only prevented anorexia due to alpha-Me-5-HT. These results suggest that stimulating either peripheral 5-HT(2) or peripheral 5-HT(1)-like receptors inhibits feeding in rats. 5-HT(1)-like sites may also mediate 5-HT-induced drinking.
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Details
- Title
- Peripherally administered alpha-methyl-5-hydroxy-tryptamine and 5-carboxamidotryptamine reduce food intake via different mechanisms in rats
- Creators
- K.J SimanskyF.C SiskA.H VaidyaK Eberle-Wang
- Publication Details
- Behavioural pharmacology, v 1(3)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Other Identifier
- 991021842660804721